C-TYPE NATRIURETIC PEPTIDE IS A GROWTH INHIBITOR OF RAT VASCULAR SMOOTH-MUSCLE CELLS
C-TYPE NATRIURETIC PEPTIDE IS A GROWTH INHIBITOR OF RAT VASCULAR SMOOTH-MUSCLE CELLS
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DOI：
10.1016/0006-291x(91)90627-j
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发表时间：
1991-06-28
影响因子：
3.1
通讯作者：
MATSUO, H
中科院分区：
文献类型：
--
作者：
FURUYA, M;YOSHIDA, M;MATSUO, H
C 型利钠肽 (CNP) 可有效刺激培养的大鼠血管平滑肌细胞 (VSMC) 中的颗粒鸟苷酸环化酶活性，抑制血清诱导的细胞 DNA 合成，其效果比 α-人心房利钠肽 (α-hANP) 有效 10 倍。 8-溴-cGMP 模拟了 CNP 的抑制作用。在离体大鼠主动脉中，CNP 也比 α-hANP 更有效地抑制 VSMC 的增殖，而该肽在 cGMP 增强和血管舒张方面的活性低于 α-hANP。这些结果表明CNP可能是VSMC的生长调节因子而不是血管舒张剂。
C-type natriuretic peptide (CNP) which potently stimulates particulate guanylate cyclase activity in cultured rat vascular smooth muscle cells (VSMC) inhibited serum-induced DNA synthesis of the cells 10-fold more effectively than α-human atrial natriuretic peptide (α-hANP). The inhibitory effect of CNP was mimicked by 8-bromo-cGMP. The proliferation of VSMC was also suppressed by CNP more potently than α-hANP, while the peptide was less active for cGMP augmentation and for vasorelaxation than α-hANP in isolated rat aorta. These results suggest that CNP may be a growth regulating factor of VSMC rather than a vasodilator.