Trait liabilities and specific promotive processes in psychopathology: The example of suicidal behavior
Trait liabilities and specific promotive processes in psychopathology: The example of suicidal behavior
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DOI：
10.1016/j.jad.2016.09.050
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发表时间：
2017-07-01
影响因子：
6.6
通讯作者：
Patrick, Christopher J.
中科院分区：
文献类型：
--
作者：
Buchman-Schmitt, Jennifer M.;Brislin, Sarah J.;Patrick, Christopher J.
背景资料：RDoC矩阵框架要求通过分析在多个测量领域量化和研究的核心生物行为过程来调查心理健康问题。批评者对RDoC提出了担忧，包括过分强调生物学概念/措施和无视多重性原则，该原则认为相同的生物倾向可以引起不同的行为结果。目前的工作说明了个体发生过程的方法来解决这些问题，集中在生物行为特征对应RDoC结构作为预测因子，自杀行为作为outcome variable.Method：数据收集从一个年轻的成年人样本（N=105），预选提高自杀率。参与者完成了自我报告的特质测量（威胁敏感性，反应抑制）和自杀特异性过程。结果：我们发现，以前报道的威胁敏感性和弱抑制控制与自杀行为的关联是由更具体的自杀促进过程介导的，即挫败的幸福感，感知的负担感和自杀能力。样本相对较小，数据是横截面的，限制了从中介分析中得出的结论。鉴于先前的研究记录了这些特质倾向的神经生理学和心理学基础，目前的工作为一个密集的RDoC导向的自杀倾向调查奠定了基础，在该调查中，使用来自不同测量领域的指标来量化特征和自杀促进过程。更广泛地说，这项工作说明了RDoC研究方法如何有助于对特定临床问题的细致入微的理解，通过考虑一般生物行为责任如何与不同的问题促进过程相结合。
Background: The RDoC matrix framework calls for investigation of mental health problems through analysis of core biobehavioral processes quantified and studied across multiple domains of measurement. Critics have raised concerns about RDoC, including overemphasis on biological concepts/measures and disregard for the principle of multifinality, which holds that identical biological predispositions can give rise to differing behavioral outcomes. The current work illustrates an ontogenetic process approach to addressing these concerns, focusing on biobehavioral traits corresponding to RDoC constructs as predictors, and suicidal behavior as the outcome variable.Method: Data were collected from a young adult sample (N=105), preselected to enhance rates of suicidality. Participants completed self-report measures of traits (threat sensitivity, response inhibition) and suicide specific processes.Results: We show that previously reported associations for traits of threat sensitivity and weak inhibitory control with suicidal behavior are mediated by more specific suicide-promoting processes namely, thwarted belongingness, perceived burdensomeness, and capability for suicide.Limitations: The sample was relatively small and the data were cross-sectional, limiting conclusions that can be drawn from the mediation analyses.Conclusions: Given prior research documenting neurophysiological as well as psychological bases to these trait dispositions, the current work sets the stage for an intensive RDoC-oriented investigation of suicidal tendencies in which both traits and suicide-promoting processes are quantified using indicators from different domains of measurement. More broadly, this work illustrates how an RDoC research approach can contribute to a nuanced understanding of specific clinical problems, through consideration of how general biobehavioral liabilities interface with distinct problem-promoting processes.