Current status of tumor markers in testicular cancer. A practical review.
Current status of tumor markers in testicular cancer. A practical review.
复制标题
睾丸癌肿瘤标志物的现状。
DOI：
10.1159/000474885
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发表时间：
1992
期刊：
影响因子：
23.4
通讯作者：
N. Javadpour
中科院分区：
文献类型：
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作者：
N. Javadpour
血清和细胞内AFP、hCG的检测对睾丸癌的认识和治疗有重要意义。在使用这些标记物时必须记住以下事件：(1)精原细胞瘤的组织学诊断，但AFP升高。通常有一种绒毛膜癌的成分。(2)精原细胞瘤和hCG升高>100 ng/ml的组织学诊断常有绒毛膜癌成分。(3)血清AFP升高的绒毛膜癌的组织学诊断。通常有一种成分是胚胎癌。(4)血清标志物升高的病理I期非精原细胞瘤性睾丸癌可分为II期或III期。(5)最近对23例强化化疗后残留的非精原细胞瘤性睾丸癌患者进行了研究，其中21例为原发肿瘤中的畸胎瘤或巨大转移灶。这些标记物在化疗后和切除前恢复正常。(6)虽然化疗后这些指标的正常化表明有效的治疗反应，但仍应利用放射学检查来观察肿瘤残留。
Detection of serum and cellular AFP and hCG has made a significant contribution in understanding and management of testicular cancer. It is essential to remember the following events in utilizing these markers: (1) Histologic diagnosis of seminoma, but AFP is elevated. There is usually an element of choriocarcinoma. (2) Histologic diagnosis of seminoma and highly elevated hCG greater than 100 ng/ml has usually an element of choriocarcinoma. (3) Histologic diagnosis of choriocarcinoma with an elevated serum AFP. There is usually an element of embryonal carcinoma. (4) Pathologic stage I nonseminomatous testicular cancer with elevated serum markers is either stage II or stage III. (5) In a recent study of 23 patients undergoing resection of residual nonseminomatous testicular cancer after intensive chemotherapy, 21 had either teratoma in primary tumor or bulky metastatic disease. The markers were normalized after chemotherapy and prior to resection. (6) Although normalization of these markers after chemotherapy indicates effective therapeutic response, one should look of residual tumor utilizing radiologic investigations.