Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species
Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species
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DOI：
10.1016/s0968-0004(02)02191-6
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发表时间：
2002-10-01
影响因子：
13.8
通讯作者：
Darley-Usmar, VM
中科院分区：
文献类型：
--
作者：
Cooper, CE;Patel, RP;Darley-Usmar, VM
信号转导的控制涉及蛋白质在关键氨基酸的翻译后修饰。半胱氨酸残基在“氧化还原”细胞信号传导途径的控制中是重要的，因为硫醇化学提供了通过结构上不同的物质进行修饰的可能性，包括来自氧化脂质、过氧化物或一氧化氮的物质。最近，一项关于转录因子OxyR中巯基修饰的重要而具有挑衅性的研究扩展了这一假设。这些发现提供了一种诱人的可能性，即细胞可以通过信号分子上单个位点的修饰来区分不同程度的氧化剂和亚硝化暴露。
The control of signal transduction involves post-translational modification of proteins at key amino acids. Cysteine residues are important in the control of 'redox' cell-signaling pathways, as thiol chemistry offers the possibility of modification by structurally diverse species, including those derived from oxidized lipids, peroxides or nitric oxide. An important and provocative study of the modification of thiols in the transcription factor OxyR recently extended this hypothesis. The findings offer the enticing possibility that the cell can distinguish between different degrees of oxidant and nitrosative exposure by modification at a single site on a signaling molecule.