Microfluidic devices for mechanical characterisation of single cells in suspension
Microfluidic devices for mechanical characterisation of single cells in suspension
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DOI：
10.1049/mnl.2011.0010
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发表时间：
2011-05-01
影响因子：
1.3
通讯作者：
Sun, Yu
中科院分区：
文献类型：
--
作者：
Zheng, Yi;Sun, Yu
这封信提供了一个概述微流控技术的单细胞机械特性。特别是，最新的文献进行了讨论，总结的工作原理和发展趋势的国家的最先进的微流控装置的机械特性的生物细胞悬浮液。根据机械刺激的作用机理，将其分为缩窄通道、流体应力、光学拉伸、电致形变、电穿孔和微流控吸管抽吸等技术。这些原则解释沿着有代表性的例子，证明他们的应用。这封信中强调的研究在实现高通量单细胞机械表征方面具有很大的潜力。
This Letter provides an overview of microfluidic technologies for single-cell mechanical characterisation. In particular, the most recent literature is discussed to summarise the working principles and development trend of the state-of-the-art microfluidic devices for mechanical characterisation of biological cells in suspension. The techniques are classified into constriction channel, fluid stress, optical stretcher, electro-deformation, electroporation and microfluidic pipette aspiration, according to the mechanism of mechanical stimuli. The principles are explained along with representative examples demonstrating their applications. The research highlighted in this letter has great potential in realising high-throughput single-cell mechanical characterisation.