Association of vitamin D receptor genotype with leprosy type
Association of vitamin D receptor genotype with leprosy type
复制标题
DOI：
10.1086/314536
复制
发表时间：
1999-01-01
影响因子：
6.4
通讯作者：
Hill, AVS
中科院分区：
文献类型：
--
作者：
Roy, S;Frodsham, A;Hill, AVS
宿主遗传因素，包括主要组织相容性复合体(MHC)基因多态性，既影响麻风本身的易感性，也影响麻风类型。非人IHC基因可能起到重要作用，但这些基因仍未确定。在加尔各答对孟加拉麻风患者的病例对照研究中，评估了两个非MHC候选基因的影响。最近的研究表明，维生素D受体(VDR)基因的变异与多种疾病的易感性有关，包括骨质疏松症和肺结核。在该人群中，VDR多态交替等位基因的纯合子分别与麻风和类结核麻风相关。基于对小鼠同系物Nramp1的研究，NRAMP1(自然耐药相关巨噬细胞蛋白1)基因可能影响人类分枝杆菌疾病的易感性。然而，未发现NRAMP1与麻风易感性有显著关联，本研究提示VDR基因多态可能通过影响宿主免疫反应的类型和强度而影响对某些疾病的易感性。
Host genetic factors including major histocompatibility complex (MHC) polymorphisms influence both susceptibility to leprosy per se and also to leprosy type. Non-h IHC genes may play an important role, but such genes remain undefined. The influence of two non-MHC candidate genes was assessed in a case-control study of Bengali leprosy patients from Calcutta, Recent studies have implicated variation in the vitamin D receptor (VDR) gene in susceptibility to several diseases, including osteoporosis and pulmonary tuberculosis, In this population, homozygotes for the alternate alleles of the VDR polymorphism are associated, respectively, with lepromatous and tuberculoid leprosy. The NRAMP1 (natural resistance associated macrophage protein 1) gene may influence human mycobacterial disease susceptibility based on studies with the murine homologue Nramp1. However, no significant association was found between NRAMP1 and leprosy susceptibility, This study suggests that the VDR polymorphism may influence susceptibility to some diseases by affecting the type and the strength of the host immune response.