Temporal interrelationships among fatigue, circadian rhythm and depression in breast cancer patients undergoing chemotherapy treatment
Temporal interrelationships among fatigue, circadian rhythm and depression in breast cancer patients undergoing chemotherapy treatment
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DOI：
10.1007/s00520-001-0317-0
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发表时间：
2002-05-01
影响因子：
3.1
通讯作者：
Andrews, PLR
中科院分区：
文献类型：
--
作者：
Roscoe, JA;Morrow, GR;Andrews, PLR
78名女性乳腺癌患者在第二和第四个研究化疗周期评估疲劳，抑郁，整体情绪和昼夜节律，作为一项更大的研究的一部分，研究帕罗西汀在减少化疗引起的疲劳的疗效。每次治疗后7 d，患者在家中完成多维度疲劳评估（MAF）、疲劳症状自评量表（FSCL）、流行病学中心抑郁量表（CES-D）、汉密尔顿抑郁量表（HDI）和心境状态量表（POMS），以评估症状严重程度。从治疗后6天开始，使用Mini-Motionlogger Actigraph（Ambulatory Monitoring，Ardsley，NY）在72小时内评估昼夜节律。通过自相关分析比较了3天内的每日睡眠和活动模式，以计算每位患者的昼夜节律评分，评分越高，干扰越少。疲劳、抑郁和情绪与第二个周期后进行的患者昼夜节律测量的比较表明，所有五个纸笔测量与昼夜节律测量相关良好（所有R（部分）
Seventy-eight female breast cancer patients were assessed for fatigue, depression, overall mood, and circadian rhythm at their second and fourth on-study chemotherapy cycles as part of a larger study examining the efficacy of paroxetine in reducing chemotherapy-induced fatigue. The Multidimensional Assessment of Fatigue (MAF), the Fatigue Symptom Checklist (FSCL), the Center for Epidemiologic Studies-Depression (CES-D) questionnaire, the Hamilton Depression Inventory (HDI), and the Profile of Mood States (POMS) were completed by patients at home 7 days after each treatment to assess symptom severity. Circadian rhythm was assessed over a 72-h period with the Mini-Motionlogger Actigraph (Ambulatory Monitoring, Ardsley, NY), starting 6 days after treatment. Daily patterns of sleep and activity were compared across the 3-day period by autocorrelation analyses to calculate a circadian rhythm score for each patient, with higher scores associated with lower disruption. Comparisons of fatigue, depression, and mood with patient circadian rhythm measures taken after the second cycle indicate that all five paper and pencil measures correlated well with the measure of circadian rhythm (all r(partial)