Treatment of myasthenia gravis with methylprednisolone pulse: a double blind study
Treatment of myasthenia gravis with methylprednisolone pulse: a double blind study
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DOI：
10.1111/j.1600-0404.1998.tb05968.x
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发表时间：
1998-06-01
影响因子：
3.5
通讯作者：
Lefvert, AK
中科院分区：
文献类型：
--
作者：
Lindberg, C;Andersen, O;Lefvert, AK
Objectives - To evaluate the efficacy and safety of one single intravenous methylprednisolone (IVMP) pulse therapy in myasthenia gravis. Material and methods - We performed a double blind placebo controlled study (2+2 g IVMP vs placebo) in patients with moderate MG. Results - A mean increase in muscle function of 27 points was found in the treatment group after one IVMP pulse as compared with a 0.7 point increase in the placebo group (P < 0.01). In the IVMP group 8 of 10 patients showed a positive treatment response. The mean duration of improvement after IVMP was 8 weeks (range 4-14 weeks). No severe side effects were found. Acetylcholine receptor antibody concentrations were unchanged in spite of the positive treatment response. Conclusions - We conclude that a single IVMP treatment is efficacious and safe in the treatment of moderate MG. (C) Munksgaard 1998.
