Micellization and sustained drug release behavior of EC-g-PPEGMA amphiphilic copolymers
Micellization and sustained drug release behavior of EC-g-PPEGMA amphiphilic copolymers
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DOI：
10.1016/j.carbpol.2010.02.017
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发表时间：
2010-06
影响因子：
11.2
通讯作者：
Junjun Tan;Yanxiang Li;Ruigang Liu;Hongliang Kang;Deqian Wang;Lin Ma;Wenyong Liu;Min Wu;Yong Huang
中科院分区：
文献类型：
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作者：
Junjun Tan;Yanxiang Li;Ruigang Liu;Hongliang Kang;Deqian Wang;Lin Ma;Wenyong Liu;Min Wu;Yong Huang
以芘为荧光探针和模型药物，研究了乙基纤维素接枝聚乙二醇甲基醚甲基丙烯酸酯共聚物（EC-g-PPEGMA）的胶束化和药物缓释行为。发现EC-g-PPEGMA共聚物具有约5×10− 4 mg/mL的低临界胶束浓度（CMC）。载药实验表明，低接枝密度的共聚物对应于较高的载药效率和较高的载药量在胶束中。芘的释放速率取决于胶束中芘侧链的长度和芘的负载量。共聚物侧链越短，胶束中共聚物与芘的比例越高，释放速率越低。这种自组装体系在药物控制释放方面具有潜在的应用前景。
The micellization and sustained drug release behavior of ethyl cellulose graft poly(poly(ethylene glycol) methyl ether methacrylate) (EC-g-PPEGMA) copolymers with well-defined structure were investigated by using pyrene as the fluorescent probe and model drug. It was found that the EC-g-PPEGMA copolymers have a low critical micelle concentration (CMC) at about 5×10−4mg/mL. Drug loading experiments indicate that a low graft density of the copolymers corresponds to a higher drug loading efficiency and a higher loading capacity of drug in the micelles. The release rate of the loaded pyrene depends on both the length of the side chains and the loading capacity of pryene in the micelles. A shorter side chain of the copolymer and a higher ratio of the copolymer to the pyrene in the micelles correspond to a lower release rate. The self-assembly system shows a potential application in controlled drug delivery.