Non‐coding RNAs in Kawasaki disease: Molecular mechanisms and clinical implications
Non‐coding RNAs in Kawasaki disease: Molecular mechanisms and clinical implications
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DOI：
10.1002/bies.202100256
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发表时间：
2022-03
期刊：
影响因子：
4
通讯作者：
Fuqing Yang;X. Ao;Lin Ding;Lin Ye;Xuejuan Zhang;Lanting Yang;Zhonghao Zhao;Jianxun Wang
中科院分区：
文献类型：
--
作者：
Fuqing Yang;X. Ao;Lin Ding;Lin Ye;Xuejuan Zhang;Lanting Yang;Zhonghao Zhao;Jianxun Wang
川崎（KD）是一种急性自限性血管炎伴冠状动脉并发症，通常发生于儿童。儿童KD发病率逐年上升，主要集中在东亚国家，但在欧美相对稳定。虽然对KD的研究已有报道，但其发病机制尚不清楚。随着高通量测序技术的发展，越来越多的调控性非编码RNA（ncRNA）包括microRNA（miRNA）、长链非编码RNA（lncRNA）和环状RNA（circRNA）被鉴定参与KD。然而，ncRNA在KD中的作用尚未得到全面阐明。因此，研究ncRNA在KD发病中的调控作用，对于探索KD的有效治疗策略具有重要意义。本文从免疫紊乱、炎症性疾病和内皮功能障碍等方面综述了近年来KD中ncRNA的研究进展，并强调了ncRNA作为KD治疗靶点的潜力。
Kawasaki disease (KD) is an acute self‐limiting vasculitis with coronary complications, usually occurring in children. The incidence of KD in children is increasing year by year, mainly in East Asian countries, but relatively stably in Europe and America. Although studies on KD have been reported, the pathogenesis of KD is unknown. With the development of high‐throughput sequencing technology, growing number of regulatory noncoding RNAs (ncRNAs) including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) have been identified to involved in KD. However, the role of ncRNAs in KD has not been comprehensively elucidated. Therefore, it is significative to study the regulatory role of ncRNA in KD, which might help to uncover new and effective therapeutic strategies for KD. In this review, we summarize recent studies on ncRNA in KD from the perspectives of immune disorders, inflammatory disorders, and endothelial dysfunction, and highlight the potential of ncRNAs as therapeutic targets for KD.