Relational integration and executive function in Alzheimer's disease.
Relational integration and executive function in Alzheimer's disease.
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阿尔茨海默病的关系整合和执行功能。
DOI：
10.1037/0894-4105.18.2.296
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发表时间：
2004
期刊：
影响因子：
2.4
通讯作者：
Miller,BruceL
中科院分区：
文献类型：
--
作者：
Waltz,JamesA;Knowlton,BarbaraJ;Holyoak,KeithJ;Boone,KyleB;Back-Madruga,Carla;McPherson,Susan;Masterman,Donna;Chow,Tiffany;Cummings,JeffreyL;Miller,BruceL
执行功能依赖于表征物体和事件之间关系的能力，而前额叶皮层为这种能力提供了神经基质。可能患有阿尔茨海默病（AD）的患者和对照组参与者被管理的工作记忆和推理的措施，在他们的关系复杂性系统地变化。AD患者表现出损害的推理措施，需要在线整合的关系，但执行以及控制参与者的非关系项目和项目需要处理的只有单一的关系。当AD患者被分为亚组的基础上，他们的表现关系推理措施，亚组表现出显着损害的关系整合措施表现出神经心理学的配置文件符合前额叶皮质功能障碍。（PsycInfo数据库记录（c）2023阿帕，保留所有权利）
Executive functions depend on the ability to represent relations between objects and events, and the prefrontal cortex provides the neural substrate for this capacity. Patients with probable Alzheimer's disease (AD) and control participants were administered measures of working memory and reasoning that varied systematically in their relational complexity. AD patients showed impairment on reasoning measures that required the online integration of relations but performed as well as control participants on nonrelational items and items requiring the processing of only single relations. When AD patients were divided into subgroups based on their performance on relational reasoning measures, the subgroup that showed significant impairment on relational integration measures exhibited a neuropsychological profile consistent with prefrontal cortical dysfunction.(PsycInfo Database Record (c) 2023 APA, all rights reserved)