Differentiating the abnormalities of social and monetary reward processing associated with depressive symptoms.
Differentiating the abnormalities of social and monetary reward processing associated with depressive symptoms.
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区分与抑郁症状相关的社会和金钱奖励处理异常。
DOI：
10.1017/s0033291720003967
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发表时间：
2020
影响因子：
6.9
通讯作者：
Gu Ruolei
中科院分区：
文献类型：
--
作者：
Zhang D;an;Shen Junshi;Bi Rong;Zhang Yueyao;Zhou Fang;Feng Chunliang;Gu Ruolei
背景奖励功能障碍是抑郁症的一个重要方面，但它在不同的奖励类型之间是否存在差异仍不清楚。方法采用事件相关电位（ERP）技术，对40例抑郁症患者和40例正常对照者完成金钱奖励延迟（MID）和社会奖励延迟（SID）任务，并进行相关分析。行为命中率和事件相关电位成分均为负变（CNV;表示奖励预期）对分组因素和奖励幅度之间的交互作用敏感;也就是说，与对照组相比，抑郁组显示出较低的命中率和较小的CNV到大幅度（但不是小幅度）的社会奖励线索。此外，这两个指标相互关联。同时，ERP组件反馈相关的负性和P3（表示奖励消费）是敏感的抑郁症的主要影响在MID和SID的任务，虽然这种效果是更突出的SID task.ConclusionsOverall，我们认为，抑郁症状与赤字在奖励预期和奖励消费阶段，特别是社会奖励。这些研究结果有可能表征包括和维持抑郁症的功能障碍的概况。
BackgroundReward dysfunction is a major dimension of depressive symptomatology, but it remains obscure if that dysfunction varies across different reward types. In this study, we focus on the abnormalities in anticipatory/consummatory processing of monetary and social reward associated with depressive symptoms.MethodsForty participants with depressive symptoms and forty normal controls completed the monetary incentive delay (MID) and social incentive delay (SID) tasks with event-related potential (ERP) recording.ResultsIn the SID but not the MID task, both the behavioral hit rate and the ERP component contingent negative variation (CNV; indicating reward anticipation) were sensitive to the interaction between the grouping factor and reward magnitude; that is, the depressive group showed a lower hit rate and a smaller CNV to large-magnitude (but not small-magnitude) social reward cues compared to the control group. Further, these two indexes were correlated with each other. Meanwhile, the ERP components feedback-related negativity and P3 (indicating reward consumption) were sensitive to the main effect of depression across the MID and SID tasks, though this effect was more prominent in the SID task.ConclusionsOverall, we suggest that depressive symptoms are associated with deficits in both the reward anticipation and reward consumption stages, particularly for social rewards. These findings have a potential to characterize the profile of functional impairment that comprises and maintains depression.