Cellular lifespan and regenerative medicine.
Cellular lifespan and regenerative medicine.
复制标题
细胞寿命和再生医学。
DOI：
10.1016/j.biomaterials.2007.05.012
复制
发表时间：
2007
期刊：
影响因子：
14
通讯作者：
Niklason,Laura
中科院分区：
文献类型：
--
作者：
Petersen,Thomas;Niklason,Laura
组织工程是一种很有前途的方法，通过开发受损或患病器官的替代组织来帮助治疗各种临床疾病。然而，此类方法将需要大量的功能性细胞群，以便产生可以复制体内功能的组织。大多数成体细胞的复制潜力有限，限制了它们在组织工程应用中的使用。因此，具有延长寿命或增加复制潜力的细胞群是人们感兴趣的。干细胞衍生的群体可能允许产生比成体分化细胞具有更高复制潜力的大细胞群体。此外，异位人端粒酶逆转录酶表达和诱导的 B 细胞淋巴瘤 2 (bcl-2) 表达可以使成体细胞比未改变的细胞更广泛地增殖。然而，端粒酶和 bcl-2 方法存在恶性转化的担忧。回顾了这些领域与组织工程和细胞寿命相关的研究现状。
Tissue engineering is a promising approach to aid in the treatment of a wide range of clinical disorders by developing replacement tissues for damaged or diseased organs. Such approaches, however, will require large and functional cell populations in order to produce a tissue that can replicate in vivo function. Most adult cells have limited replicative potential that limits their use in tissue engineering applications. Thus, cell populations with expanded lifespan or increased replicative potential are of interest. Stem cell-derived populations may allow the creation of large cell populations that have increased replicative potential over adult differentiated cells. In addition, ectopic human telomerase reverse transcriptase expression and induced B-cell lymphoma 2 (bcl-2) expression can allow adult cells to proliferate more extensively than unaltered cells. However, concerns for malignant transformation exist with telomerase and bcl-2 approaches. The current states of research in these areas are reviewed as they relate to tissue engineering and the cellular lifespan.