The effect of olive leaf extract in decreasing the expression of two pro-inflammatory cytokines in patients receiving chemotherapy for cancer. A randomized clinical trial
The effect of olive leaf extract in decreasing the expression of two pro-inflammatory cytokines in patients receiving chemotherapy for cancer. A randomized clinical trial
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DOI：
10.1016/j.sdentj.2013.09.001
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发表时间：
2013-10-01
影响因子：
1.8
通讯作者：
Ahmed, Khadija Muhamed
中科院分区：
文献类型：
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作者：
Ahmed, Khadija Muhamed
背景：口腔粘膜炎是所有癌症强化治疗方案中化疗最常见的副作用，也是头颈部放疗最常见的副作用。对于蒸汽细胞移植，它也被认为是最衰弱的副作用。本研究的目的：本研究的目的是评价含有橄榄叶提取物(OLE)的含漱剂预防化疗患者严重口腔粘膜炎的效果，并评估其在减少化疗后促炎细胞因子产生方面的作用。材料和方法：本研究采用安慰剂对照、随机、双盲、交叉设计。25名接受强化化疗的患者被随机分配到3个不同的化疗周期中接受含有OLE、盐酸苯达明或安慰剂的含漱液。使用世界卫生组织标准和口腔霉菌炎评定量表评估口腔粘膜炎的严重程度。每个周期每周对患者进行评估，直到化疗后15天。用酶联免疫吸附试验检测唾液中白介素1β(IL-1β)和肿瘤坏死因子-α(TNF-α)的水平。结果：OLE组和苯达明组2周后口腔粘膜炎的发生率和严重程度均显著低于安慰剂组。OLE组IL-1β和TNF-α水平明显低于其他两组。结论：初步研究结果表明，OLE能有效降低化疗后IL-1β和TNF-α水平，对重度口腔黏膜炎有一定的治疗作用和预防作用。(C)2013年，爱思唯尔公司代表沙特国王大学制作和主办。
Background: Oral mucositis is the most common side effects of chemotherapy of all cancer with intensive treatments regimen, and is the most common side effects of head and neck radiation therapy. For steam cell transplantation, its also regarded as the most debilitating side effects.Aims of the study: The objectives of this study were to assess the effect of a mouth rinse containing olive leaf extract (OLE) in preventing severe oral mucositis in patients receiving chemotherapy, and to estimate its effect in decreasing pro-inflammatory cytokine production after chemotherapy.Materials and methods: This study utilized a placebo-controlled, randomized, double-blind, and cross-over design. Twenty-five patients undergoing intensive chemotherapy were randomly assigned to receive a mouth wash containing OLE, benzydamine hydrochloride, or placebo in 3 different cycles of chemotherapy. Oral mucositis severity was assessed using the World Health Organization criteria and Oral Mycositis Assessment Scale. Patients were evaluated weekly until 15 days after chemotherapy for each cycle. Salivary levels of interleukin-1 beta (IL-1 beta) and tumor necrosis factor- alpha (TNF-alpha) were evaluated by enzyme-linked immunosorbant assay.Results: Oral mucositis rates and severity after 2 weeks were significantly lower in the OLE and benzydamine groups compared to the placebo group. The IL-1 beta and TNF-alpha levels were significantly decreased in the OLE group compared to the other groups.Conclusion: Preliminary findings indicate that OLEis effective in reducing IL-1 beta and TNF-alpha levels after chemotherapy and exert a therapeutic effect and prevent development of severe oral mucositis. (C) 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.