Effects of aerobic exercise and resistance training on lipid profiles and inflammation status in patients on maintenance hemodialysis.
Effects of aerobic exercise and resistance training on lipid profiles and inflammation status in patients on maintenance hemodialysis.
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DOI：
10.4103/0971-4065.73442
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发表时间：
2010-10-01
影响因子：
0.8
通讯作者：
Sanavi, S
中科院分区：
文献类型：
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作者：
Afshar, R;Shegarfy, L;Sanavi, S
身体功能受限是慢性血液透析（HD）患者常见的疾病，与发病率和死亡率增加有关。本研究的目的是确定有氧和阻力训练对血液透析患者血脂和炎症状态的影响。在德黑兰的HD单位接受常规维持HD的30例男性志愿者中，入组了21例受试者。将患者随机分为有氧运动组、抗阻训练组和对照组，每组7例，抗阻训练组接受为期8周的透析中运动计划（3次/周）。有氧组采用12 ~ 16/20的强度，按博格量表（RPE）进行10-30 min的固定踏车训练;阻力组采用踝负重进行膝关节伸展、髋关节外展和屈曲，按博格量表（RPE）进行15 ~ 17/20的强度训练。在基线和第8周抽取空腹血液样本进行血清生化检查。年龄、HD持续时间和体力活动评分分别为51.6± 18.9岁、25.1±13.9个月和19.2±7.6。糖尿病（43%）、高血压（28%）和梗阻性尿路病（14%）是最常见的基础疾病。有氧运动和抗阻运动与血肌酐水平相关（P< 0.0001和P <0.05）。透析中有氧运动和抗阻运动均显示对炎症状态的有益作用，而对血脂水平无任何影响，这可能是由于研究持续时间短，不伴有体重变化。运动过程中溶质清除没有变化。有必要对运动在HD患者中的作用进行更多的研究。
Physical function limitation is a common disorder in chronic hemodialysis (HD) patients, relating to increased morbidity and mortality. The aim of this study was to determine the effects of aerobic and resistance trainings on blood lipids and inflammation status in HD patients. Out of 30 volunteer males who had been undergoing conventional maintenance HD within an HD unit in Tehran, 21 subjects were enrolled. They were randomly assigned into aerobic exercise group - resistance training group undergoing an 8-week intradialytic exercise program (three times/week) and control group (n = 7, each). Training program consisted of 10-30 min stationary cycling at an intensity of 12-16 out of 20 at the rate of perceived exertion (RPE) of Borg scale in aerobic group and using ankle weights for knee extension, hip abduction and flexions at an intensity of 15-17 out of 20 at the RPE of Borg scale in resistance group. Fasting blood samples for serum biochemistry were drawn at baseline and 8 weeks. The age, HD duration, and physical activity score were 51.6±18.9yrs; 25.1±13.9 mo, and 19.2±7.6, respectively. Diabetes mellitus (43%), hypertension (28%), and obstructive uropathy (14%) were the most common underlying diseases. Aerobic and resistance exercises were correlated with serum creatinine (P< 0.0001 and P0.05). Both intradialytic aerobic and resistance exercises showed beneficial effects on inflammation status without any influences on serum lipid levels probably due to short duration of the study which was not accompanied with body weight changes. Solute removal had no change during exercise programs. There is a need for more investigation on the role of exercise in HD patients.