The accelerated aging skin in rhino-like SHJHhr mice
The accelerated aging skin in rhino-like SHJHhr mice
复制标题
犀牛皮肤加速老化——SHJH hr 小鼠
DOI：
10.1111/exd.14632
复制
发表时间：
2022-07-03
影响因子：
3.6
通讯作者：
Zhao，Yuhong
中科院分区：
文献类型：
--
作者：
Gao，Jinfeng;Li，Yongchao;Zhao，Yuhong
SHJHhrmice line is rhino‐like mice with a nonsenseHairless(Hr) mutant, which shows the characteristic of shedding hair and wrinkled skin with increasing age. Through histological analysis and aging indexes detection, SHJHhrmice show an increased thickness skin with degraded hair follicle and dermal cysts and disorganized collagen fibres, as well as decreased level of Hyp. Meanwhile, the aging markers p16 and p21 are significantly higher in SHJHhrmouse skin than ICR mouse skin at same age. Moreover, the data of MDA and SOD show a higher oxidative stress in SHJHhrmouse skin, and the levels of Nrf2 and its targets are significantly downregulated, which suggests SHJHhrmice have a faster aging skin and its reason maybe poor antioxidative protection. Overall, this study shows SHJHhrmice with an accelerated aging skin, which suggests the role ofHrgene in skin aging.
