Visual Responsiveness of Neurons in the Secondary Somatosensory Area and its Surrounding Parietal Operculum Regions in Awake Macaque Monkeys.
Visual Responsiveness of Neurons in the Secondary Somatosensory Area and its Surrounding Parietal Operculum Regions in Awake Macaque Monkeys.
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DOI：
10.1093/cercor/bhv095
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发表时间：
2015-11
期刊：
影响因子：
--
通讯作者：
Iriki A
中科院分区：
文献类型：
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作者：
Hihara S;Taoka M;Tanaka M;Iriki A
先前在猕猴中进行的神经生理学研究表明，次级体感皮层（SII）主要参与体感信息的处理，并且没有其他感觉输入的报道。相反，最近的人类大脑成像研究揭示了视觉和听觉刺激对SII活动的影响，这表明人类SII中的多感觉整合。为了确定是否SII的多感官反应也存在于非人灵长类动物中，我们记录了单一的单位活动响应视觉和听觉刺激的SII和周围地区的8个半球从6个清醒的猴子。在记录的1157个神经元中，有306个神经元对视觉刺激有反应。这些视觉神经元通常对相当复杂的刺激做出反应，例如对周围空间的刺激（40.5%），对人类行为的观察（29.1%）和猴子触及范围之外的移动物体刺激（23.9%）。我们偶尔对视觉神经元施加听觉刺激，发现10个听觉反应神经元表现出体感反应。视觉神经元沿着外侧沟连续分布，覆盖整个SII区，与其他躯体感觉神经元沿着一致。这些结果突出了需要调查新的功能角色，而不是躯体感觉处理的SII。
Previous neurophysiological studies performed in macaque monkeys have shown that the secondary somatosensory cortex (SII) is essentially engaged in the processing of somatosensory information and no other sensory input has been reported. In contrast, recent human brain-imaging studies have revealed the effects of visual and auditory stimuli on SII activity, which suggest multisensory integration in the human SII. To determine whether multisensory responses of the SII also exist in nonhuman primates, we recorded single-unit activity in response to visual and auditory stimuli from the SII and surrounding regions in 8 hemispheres from 6 awake monkeys. Among 1157 recorded neurons, 306 neurons responded to visual stimuli. These visual neurons usually responded to rather complex stimuli, such as stimulation of the peripersonal space (40.5%), observation of human action (29.1%), and moving-object stimulation outside the monkey's reach (23.9%). We occasionally applied auditory stimuli to visual neurons and found 10 auditory-responsive neurons that exhibited somatosensory responses. The visual neurons were distributed continuously along the lateral sulcus covering the entire SII, along with other somatosensory neurons. These results highlight the need to investigate novel functional roles—other than somesthetic sensory processing—of the SII.