Ferret hepatitis E virus infection induces acute hepatitis and persistent infection in ferrets
Ferret hepatitis E virus infection induces acute hepatitis and persistent infection in ferrets
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DOI：
10.1016/j.vetmic.2015.11.014
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发表时间：
2016-02-01
影响因子：
3.3
通讯作者：
Wakita, Takaji
中科院分区：
文献类型：
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作者：
Li, Tian-Cheng;Yang, Tingting;Wakita, Takaji
雪貂戊型肝炎病毒（FerretHepatitisEvirus，HEV）是一种在雪貂体内发现的新型戊型肝炎病毒。然而，雪貂HEV的致病性仍不清楚。在本研究中，我们比较了从美国进口到日本之前和之后的63只雪貂的HEV RNA阳性率和丙氨酸氨基转移酶（ALT）水平。结果表明，雪貂HEV-RNA阳性率由12.7%（8/63）上升到60.3%（38/63），其中65.8%（25/38）的雪貂ALT升高，提示雪貂HEV感染是引起肝脏损害的重要原因。从雪貂HEV感染的长期监测中，我们确定雪貂的这种感染表现出三种模式：亚临床感染、急性肝炎和持续感染。在初次感染实验中，在感染HEV的雪貂中也观察到ALT升高。这些结果表明，雪貂HEV感染可引起急性肝炎和持续性感染，提示雪貂是戊型肝炎免疫学和病理学研究的一个候选动物模型。(C)2015 Elsevier B. V.版权所有。
Ferret hepatitis E virus (HEV), a novel hepatitis E virus, has been identified in ferrets. However, the pathogenicity of ferret HEV remains unclear. In the present study, we compared the HEV RNA-positivity rates and alanine aminotransferase (ALT) levels of 63 ferrets between before and after import from the US to Japan. We found that the ferret HEV-RNA positivity rates were increased from 12.7% (8/63) to 603% (38/63), and ALT elevation was observed in 65.8% (25/38) of the ferret HEV RNA-positive ferrets, indicating that ferret HEV infection is responsible for liver damage. From long term-monitoring of ferret HEV infection we determined that this infection in ferrets exhibits three patterns: sub-clinical infection, acute hepatitis, and persistent infection. The ALT elevation was also observed in ferret HEV-infected ferrets in a primary infection experiment. These results indicate that the ferret HEV infection induced acute hepatitis and persistent infection in ferrets, suggesting that the ferrets are a candidate animal model for immunological as well as pathological studies of hepatitis E. (C) 2015 Elsevier B.V. All rights reserved.