Resistin, an Adipokine with Non-Generalized Actions on Sympathetic Nerve Activity.
Resistin, an Adipokine with Non-Generalized Actions on Sympathetic Nerve Activity.
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DOI：
10.3389/fphys.2015.00321
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发表时间：
2015
影响因子：
4
通讯作者：
Stebbing MJ
中科院分区：
文献类型：
--
作者：
Badoer E;Kosari S;Stebbing MJ
世界卫生组织称肥胖是一种全球流行病。体重增加和血压之间有很强的联系。血压的一个主要决定因素是支配心血管器官的交感神经的活动水平。在人类和动物模型中，肥胖的一个特征是骨骼肌血管系统和肾脏的交感神经活动增加。肥胖现在被认为是一种慢性、低水平的炎症，促炎细胞因子升高，包括脂肪组织产生的细胞因子。从脂肪组织中释放的最著名的脂肪因子是瘦素。脂肪因子，抵抗素，也从脂肪组织中释放出来。抵抗素可作用于中枢神经系统，影响交感神经的活动。在这里，我们回顾抵抗素对交感神经活动的影响，并将其与瘦素进行比较。我们认为抵抗素和瘦素可能有复杂的相互作用。首先，它们可以相互增强，因为它们都对支配心血管器官的交感神经具有兴奋性；相反，它们对棕色脂肪组织（一个关键的代谢器官）的作用可能相互拮抗。这些相互作用在瘦素和抵抗素升高的情况下可能很重要，比如肥胖。
The World Health Organization has called obesity a global epidemic. There is a strong association between body weight gain and blood pressure. A major determinant of blood pressure is the level of activity in sympathetic nerves innervating cardiovascular organs. A characteristic of obesity, in both humans and in animal models, is an increase in sympathetic nerve activity to the skeletal muscle vasculature and to the kidneys. Obesity is now recognized as a chronic, low level inflammatory condition, and pro-inflammatory cytokines are elevated including those produced by adipose tissue. The most well-known adipokine released from fat tissue is leptin. The adipokine, resistin, is also released from adipose tissue. Resistin can act in the central nervous system to influence the sympathetic nerve activity. Here, we review the effects of resistin on sympathetic nerve activity and compare them with leptin. We build an argument that resistin and leptin may have complex interactions. Firstly, they may augment each other as both are excitatory on sympathetic nerves innervating cardiovascular organs; In contrast, they could antagonize each other's actions on brown adipose tissue, a key metabolic organ. These interactions may be important in conditions in which leptin and resistin are elevated, such as in obesity.