Effect of Crystallization Conditions on the Metastable Zone Width and Nucleation Kinetics of p ‐Aminobenzoic Acid in Ethanol
Effect of Crystallization Conditions on the Metastable Zone Width and Nucleation Kinetics of
p
‐Aminobenzoic Acid in Ethanol
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结晶条件对乙醇中对氨基苯甲酸介稳区宽度和成核动力学的影响
DOI：
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发表时间：
2020
影响因子：
2.1
通讯作者：
T. Mahmud
中科院分区：
文献类型：
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作者：
Siti Fatimah Mohd Noor;D. Camacho;Cai Y. Ma;T. Mahmud
对亚稳区宽度（MSZW）和成核动力学的详细了解对于间歇冷却结晶过程的设计至关重要。冷却速率和叶轮转速等因素影响MSZW和成核动力学。在0.5 l搅拌槽结晶器中，测定了乙醇对氨基苯甲酸（pABA）间歇冷却结晶过程中结晶温度和溶解温度随冷却速率和叶轮转速的变化规律。采用Nyvlt和基于第一原理的Kashchiev-Borissova-Hammond-Roberts （kbbr）方法对多热实验数据进行了分析。在所有的实验情况下，后一种模型显示pABA在乙醇中的成核过程以瞬时成核机制为主。Nyvlt和KBHR分析提供了一系列与幂律模型相关的参数值，该模型描述了成核速率和核浓度。
A detailed knowledge of the metastable zone width (MSZW) and nucleation kinetics is vital for the design of batch cooling crystallization processes. Factors such as cooling rate and impeller speed affect the MSZW and nucleation kinetics. Crystallization and dissolution temperatures were measured as a function of cooling rate and impeller speed during the batch cooling crystallization of p -amino-benzoic acid (pABA) from ethanol in a 0.5-L stirred-tank crystallizer. The polythermal experimental data were analyzed using the Nyvlt and first principles-based Kashchiev-Borissova-Hammond-Roberts (KBHR) methods. In all experimental cases, the latter model revealed that the nucleation process of pABA in ethanol was dominated by an instantaneous nucleation mechanism. The Nyvlt and KBHR analyses delivered a range of parameter values associated with a power-law model describing the nucleation rate as well as the concentration of nuclei.
影响因子：
3.9
作者：
V. Nappo;R. Sullivan;R. Davey;S. Kuhn;A. Gavriilidis;L. Mazzei
通讯作者：
V. Nappo;R. Sullivan;R. Davey;S. Kuhn;A. Gavriilidis;L. Mazzei
影响因子：
3.1
作者：
Corzo, Diana M. Camacho;Borissova, Antonia;More, Iain
通讯作者：
More, Iain