Feasibility of asymmetric stretch assessment in the ascending aortic wall with DENSE cardiovascular magnetic resonance.
Feasibility of asymmetric stretch assessment in the ascending aortic wall with DENSE cardiovascular magnetic resonance.
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DOI：
10.1186/1532-429x-16-6
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发表时间：
2014-01-09
期刊：
影响因子：
--
通讯作者：
Saloner D
中科院分区：
文献类型：
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作者：
Haraldsson H;Hope M;Acevedo-Bolton G;Tseng E;Zhong X;Epstein FH;Ge L;Saloner D
血管直径是临床评估主动脉疾病的主要成像参数，但在正常直径下可能发生不良事件。主动脉僵硬度已被研究为一个额外的基于成像的风险因素，并已被证明是一个独立的预测心血管发病率和全因死亡率。报告表明，一些主动脉病变在血管周围不对称，这是当前成像方法无法识别的特征。我们建议，这种不对称性可以使用位移编码与刺激回波（DENSE）。本研究的目的是探讨使用DENSE评估健康和患病上行动脉的不对称拉伸的可行性。在5名志愿者和15名连续患者中使用DENSE心血管磁共振（CMR）评估主动脉壁位移。在肺动脉处通过升主动脉的横截面中进行分析。位移数据用于确定主动脉周围四个象限中主动脉扩张和静息状态之间的壁拉伸。方差分析（ANOVA）不仅显示志愿者组之间的拉伸存在显著差异（p < 0.001），而且显示主动脉圆周沿着的拉伸也存在显著差异（p < 0.001），表明拉伸模式不对称。此外，志愿者和不同患者组之间的不对称性存在显著差异（p < 0.01）。使用DENSE CMR评估升主动脉的不对称牵拉是可行的。在患者和志愿者之间观察到明显的拉伸差异，在主动脉圆周周围显示出不对称的模式。
Vessel diameter is the principal imaging parameter assessed clinically for aortic disease, but adverse events can occur at normal diameters. Aortic stiffness has been studied as an additional imaging-based risk factor, and has been shown to be an independent predictor of cardiovascular morbidity and all-cause mortality. Reports suggest that some aortic pathology is asymmetric around the vessel circumference, a feature which would not be identified with current imaging approaches. We propose that this asymmetry may be revealed using Displacement Encoding with Stimulated Echoes (DENSE). The objective of this study is to investigate the feasibility of assessing asymmetric stretch in healthy and diseased ascending aortas using DENSE. Aortic wall displacement was assessed with DENSE cardiovascular magnetic resonance (CMR) in 5 volunteers and 15 consecutive patients. Analysis was performed in a cross-sectional plane through the ascending aorta at the pulmonary artery. Displacement data was used to determine the wall stretch between the expanded and resting states of the aorta, in four quadrants around the aortic circumference. Analysis of variance (ANOVA) did not only show significant differences in stretch between groups of volunteers (p < 0.001), but also significant differences in stretch along the circumference of the aorta (p < 0.001), indicating an asymmetric stretch pattern. Furthermore, there is a significant difference in the asymmetry between volunteers and different groups of patients (p < 0.01). Evaluation of asymmetric stretch is feasible in the ascending aorta with DENSE CMR. Clear differences in stretch are seen between patients and volunteers, with asymmetric patterns demonstrated around the aortic circumference.