Omega-3 polyunsaturated fatty acids and psychological intervention for workers with mild to moderate depression: A double-blind randomized controlled trial.
Omega-3 polyunsaturated fatty acids and psychological intervention for workers with mild to moderate depression: A double-blind randomized controlled trial.
复制标题
Omega-3 多不饱和脂肪酸和对轻度至中度抑郁症工人的心理干预：一项双盲随机对照试验。
DOI：
10.1016/j.jad.2018.11.039
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发表时间：
2018
影响因子：
6.6
通讯作者：
S.
中科院分区：
文献类型：
--
作者：
TAYAMA;J.;OGAWA;S.;NAKAYA;N.;SONE;T.;HAMAGUCHI;T.;TAKEOKA;A.;HAMAZAKI;K.;OKAMURA;H.;YAJIMA;J.;KOBAYASHI;M.;HAYASHIDA;M.;SHIRABE;S.
BackgroundThis study assessed whether a combined intervention of omega-3 polyunsaturated fatty acids（PUFAs）and psychoeducation better improved mild to moderate depression in workers compared to psychoeducation onesel.MethodsThis study is a double-blinded，parallel group，randomized controlled trial that compared the intervention group，receiving omega-3 fatty acids，with a control group，receiving a placebo supplementary.接受omega-3脂肪酸的参与者每天服用15 × 300 mg胶囊，持续12周。omega-3 PUFA的每日总剂量为500 mg二十二碳六烯酸和1000 mg二十碳五烯酸（EPA）。Beck Depression Inventory®-II（BDI-II）用于评估治疗后抑郁症的严重程度。结果治疗12周后，安慰剂组和omega-3组的BDI-II评分显著低于各自的基线评分（安慰剂组：t = − 4. 6，p <0. 01; Omega-3组：t = − 7. 3，p <0. 01）。然而，在治疗12周后，我们发现两组之间在BDI-II评分变化方面没有显著差异（0.7; 95%CI，-0.7至2.1; p = 0.30）。此外，我们的研究结果可能无法推广到其他regions.ConclusionsThe结果表明，欧米茄-3脂肪酸和心理教育和心理教育的组合可以单独有助于改善轻度至中度抑郁症患者的症状。然而，在改善抑郁症症状方面，干预措施之间没有差异。
BackgroundThis study assessed whether a combined intervention of omega-3 polyunsaturated fatty acids (PUFAs) and psychoeducation better improved mild to moderate depression in workers compared to psychoeducation alone.MethodsThis study was a double-blinded, parallel group, randomized controlled trial that compared the intervention group, receiving omega-3 fatty acids, with a control group, receiving a placebo supplement. Participants receiving omega-3 fatty acids took 15 × 300 mg capsules per day for 12 weeks. The total daily dose of omega-3 PUFAs was 500 mg docosahexaenoic acid and 1000 mg eicosapentaenoic acid (EPA). The Beck Depression Inventory®-II (BDI-II) was used to assess the severity of depression after treatment.ResultsAfter 12 weeks of treatment, BDI-II scores were significantly lower in the placebo and omega-3 group, when compared to their respective baseline scores (Placebo: t = − 4.6, p < 0.01; Omega-3: t = − 7.3, p < 0.01). However, after 12 weeks of treatment, we found no significant difference between both groups with respect to changes in the BDI-II scores (0.7; 95% CI, − 0.7 to 2.1; p = 0.30).LimitationsThis study did not measure blood omega-3 fatty acid concentration and presented a high-dropout rate. Moreover, our results may not be generalizable to other regions.ConclusionsThe results show that a combination of omega-3 fatty acids and psychoeducation and psychoeducation alone can contribute to an improvement in symptoms in people with mild to moderate depression. However, there is no difference between the interventions in ameliorating symptoms of depression.