Defining the evolutionary and gene regulatory logic of vertebrate neuronal diversity.

Defining the evolutionary and gene regulatory logic of vertebrate neuronal diversity.
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定义脊椎动物神经元多样性的进化和基因调控逻辑。

DOI:
10.1016/j.neuron.2021.12.013
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发表时间:
2022
期刊:
影响因子:
16.2
通讯作者:
delaTorre-Ubieta,Luis
delaTorre-Ubieta,Luis
中科院分区:
医学1区
文献类型:
--
作者:
delaTorre-Ubieta,Luis

文献摘要

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脊椎动物大脑中精致的细胞复杂性是如何实现的?在这一期的《神经元》杂志中,Closser et al.(2022)揭示了扩展的神经元基因调控景观可以通过提供效应基因的复杂背景和细胞特异性控制来驱动进化的细胞多样化。
How is the exquisite cellular complexity of the vertebrate brain achieved? In this issue ofNeuron, Closser et al. (2022) reveal that an expanded neuronal gene regulatory landscape may drive evolutionary cellular diversification by providing complex context and cell-specific control of effector genes.