Epithelial Organization: The Gut and Beyond.
Epithelial Organization: The Gut and Beyond.
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DOI：
10.1002/cphy.c170003
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发表时间：
2017-09
影响因子：
5.8
通讯作者：
N. Shashikanth;Sunil Yeruva;M. D. M. Ong-M.-D.-M.-Ong-24962981;M. Odenwald;R. Pavlyuk;J. Turner
中科院分区：
文献类型：
--
作者：
N. Shashikanth;Sunil Yeruva;M. D. M. Ong-M.-D.-M.-Ong-24962981;M. Odenwald;R. Pavlyuk;J. Turner
上皮细胞对复杂生物体的生存和体内平衡至关重要。这些细胞覆盖在所有粘膜、皮肤和其他对生理功能至关重要的区隔结构的表面。除了维持分隔内外室的屏障外，上皮还表现出多种器官特异性分化功能。功能反映在上皮的整体结构和组织、单个细胞的形状以及这些细胞表达的蛋白质上。一个器官中通常存在一种以上的上皮细胞类型，在许多情况下，单个细胞分化以改变其功能行为，作为正常发育的一部分或对细胞外刺激的反应。本文从总体上讨论了上皮结构和功能的多样性，并更深入地探讨了代表性组织，以突出器官的特定功能及其对生理和疾病的贡献。©2017美国生理学会。中国生物医学工程学报（英文版），2017。
Epithelial cells are essential to the survival and homeostasis of complex organisms. These cells cover the surfaces of all mucosae, the skin, and other compartmentalized structures essential to physiological function. In addition to maintenance of barriers that separate internal and external compartments, epithelia display a variety of organ-specific differentiated functions. Function is reflected in overall epithelial structure and organization, shape of individual cells, and proteins expressed by these cells. More than one epithelial cell type is often present within a single organ and, in many cases, individual cells differentiate to change their functional behaviors as part of normal development or in response to extracellular stimuli. This article discusses the diversity of epithelial structure and function in general terms and explores representative tissues in greater depth to highlight organ specific functions and their contributions to physiology and disease. © 2017 American Physiological Society. Compr Physiol 7:1497-1518, 2017.