Distinct Immunologic Properties of Soluble Versus Particulate Antigens.
Distinct Immunologic Properties of Soluble Versus Particulate Antigens.
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DOI：
10.3389/fimmu.2018.00598
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发表时间：
2018
影响因子：
7.3
通讯作者：
Snapper CM
中科院分区：
文献类型：
--
作者：
Snapper CM
与可溶性抗原相比，颗粒状抗原具有不同的免疫学特性。了解这些不同形式的抗原参与的不同免疫途径的机制和功能后果对疫苗的设计特别相关。这也与临床医学中治疗性人类蛋白的使用有关，这些蛋白已被证明聚集在一起，并可能因此引发自身抗体。
Antigens in particulate form have distinct immunologic properties relative to soluble antigens. An understanding of the mechanisms and functional consequences of the distinct immunologic pathways engaged by these different forms of antigen is particularly relevant to the design of vaccines. It is also relevant regarding the use of therapeutic human proteins in clinical medicine that have been shown to aggregate, and perhaps as a result, elicit autoantibodies.