Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes
Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes
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DOI：
10.1212/wnl.59.5.746
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发表时间：
2002-09-10
期刊：
影响因子：
9.9
通讯作者：
Breteler, MMB
中科院分区：
文献类型：
--
作者：
den Heijer, T;Oudkerk, M;Breteler, MMB
APOE 基因的 epsilon4 等位基因会增加 AD 风险，而 epsilon2 等位基因可能具有保护作用。作者评估了 APOE 基因型对海马、杏仁核和全脑萎缩的影响，将其作为非痴呆人群临床前 AD 的假定标志物。 epsilon4 携带者比 epsilon3 epsilon3 受试者有更多的海马和杏仁核萎缩，但没有更多的全脑萎缩。 epsilon2 携带者的脑萎缩并不比 epsilon3 epsilon3 受试者少。
The epsilon4 allele of the APOE gene increases the risk for AD, whereas the epsilon2 allele may be protective. The authors assessed the impact of APOE genotype on hippocampal, amygdalar, and global brain atrophy as putative markers of preclinical AD in a nondemented population. Carriers Of epsilon4 had significantly more hippocampal and amygdalar atrophy than epsilon3epsilon3 subjects, but not more global brain atrophy. Carriers of epsilon2 did not have less brain atrophy than epsilon3epsilon3 subjects.