Setting priorities for a research agenda to combat drug-resistant tuberculosis in children
Setting priorities for a research agenda to combat drug-resistant tuberculosis in children
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DOI：
10.5588/pha.15.0047
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发表时间：
2015-12-21
影响因子：
1.4
通讯作者：
Swaminathan, S.
中科院分区：
文献类型：
--
作者：
Velayutham, B.;Nair, D.;Swaminathan, S.
背景：许多知识差距阻碍了儿童耐药结核病 (TB) 的预防和治疗。确定研究重点对于为解决这一被忽视的问题提供信息和制定策略至关重要。目标：系统地确定儿童耐药结核病的研究重点并对其进行排名。设计：采用儿童健康和营养研究计划 (CHNRI) 方法，我们编制了四个研究领域的 53 个研究问题，然后将这些问题分为三种研究类型。我们邀请儿童耐药结核病专家通过在线调查对这些问题进行评分。结果：共有81名受访者参与了调查。排名第一的研究问题是确定现有诊断工具的最佳组合以进行早期诊断。排名靠前的治疗相关问题集中在改善治疗结果的原因和干预措施、药物的不良反应和最佳治疗持续时间。耐药结核病的患病率是流行病学领域排名最高的问题。排名最高的发展类型问题集中在最佳诊断、治疗和治疗提供方式的干预措施上。结论：这是首次确定儿童耐药结核病的研究重点并对其进行排名。该成果是指导改善儿童耐药结核病预防和治疗研究的资源。
Setting: Numerous knowledge gaps hamper the prevention and treatment of childhood drug-resistant tuberculosis (TB). Identifying research priorities is vital to inform and develop strategies to address this neglected problem.Objective: To systematically identify and rank research priorities in childhood drug-resistant TB.Design: Adapting the Child Health and Nutrition Research Initiative (CHNRI) methodology, we compiled 53 research questions in four research areas, then classified the questions into three research types. We invited experts in childhood drug-resistant TB to score these questions through an online survey.Results: A total of 81 respondents participated in the survey. The top-ranked research question was to identify the best combination of existing diagnostic tools for early diagnosis. Highly ranked treatment-related questions centred on the reasons for and interventions to improve treatment outcomes, adverse effects of drugs and optimal treatment duration. The prevalence of drug-resistant TB was the highest-ranked question in the epidemiology area. The development type questions that ranked highest focused on interventions for optimal diagnosis, treatment and modalities for treatment delivery.Conclusion: This is the first effort to identify and rank research priorities for childhood drug-resistant TB. The result is a resource to guide research to improve prevention and treatment of drug-resistant TB in children.