Iridium-catalyzed allylic alkylation of monosubstituted allylic acetates with azlactone, and separation of diastereoisomers by sequential aza-Cope rearrangement
Iridium-catalyzed allylic alkylation of monosubstituted allylic acetates with azlactone, and separation of diastereoisomers by sequential aza-Cope rearrangement
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DOI：
10.1016/j.tet.2011.08.016
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发表时间：
2011-10-07
期刊：
影响因子：
2.1
通讯作者：
Itoh, Toshiyuki
中科院分区：
文献类型：
--
作者：
Kawatsura, Motoi;Tsuji, Hiroaki;Itoh, Toshiyuki
演示了铱催化的二氢唑酮烯丙基烷基化和连续的 aza-Cope 重排。连续反应有效分离非对映异构体并提供非对映异构体纯的吖内酯衍生物和恶唑啉酮衍生物。 (C) 2011 Elsevier Ltd. 保留所有权利。
The iridium-catalyzed allylic alkylation with azlactone and sequential aza-Cope rearrangement was demonstrated. The sequential reaction was effective in separating of diastereoisomers and afforded a diastereomerically pure azlactone derivative and oxazolinone derivative. (C) 2011 Elsevier Ltd. All rights reserved.