1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus.
1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus.
复制标题
DOI：
10.1021/acs.jnatprod.5b00604
复制
发表时间：
2016-03-25
影响因子：
5.1
通讯作者：
MacMillan JB
中科院分区：
文献类型：
--
作者：
Fu P;La S;MacMillan JB
从海洋来源的旋毛链霉菌SNB-048菌株中分离得到2个新的1，3-恶嗪-6-酮衍生物(1和2)和6个新的波西米胺型吡咯里西丁生物碱(3-8)。通过光谱分析、电子捕获光谱、量子化学计算和化学方法对其结构和绝对构型进行了全面的表征。化合物1和2具有γ-内酰胺部分和1，3-恶嗪-6-酮体系。
Two new 1,3-oxazin-6-one derivatives (1 and 2) and six new bohemamine-type pyrrolizidine alkaloids (3–8) were isolated from the marine-derived Streptomyces spinoverrucosus strain SNB-048. Their structures including the absolute configurations were fully elucidated on the basis of spectroscopic analysis, ECD spectra, quantum chemical calculations, and chemical methods. Compounds 1 and 2 possess a γ-lactam moiety and a 1,3-oxazin-6-one system.