An efficient and general approach to β-functionalized ketones
An efficient and general approach to β-functionalized ketones
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DOI：
10.1021/ol070159h
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发表时间：
2007-03-29
期刊：
影响因子：
5.2
通讯作者：
Flowers, Robert A., II
中科院分区：
文献类型：
--
作者：
Jiao, Jingliang;Nguyen, Larry X.;Flowers, Robert A., II
在取代的环丙醇存在下，硝酸铈铵（CAN）氧化选定的阴离子（N-3(-), SCN-， I-和Br-）为β功能化酮提供了一种新的方法。该方案有许多优点，包括反应时间短，易于试剂处理，温和，中性的反应条件。总的来说，这种方法为有机合成中重要的起始材料和中间体提供了另一种途径。
The oxidation of selected anions (N-3(-), SCN-, I-, and Br-) by ceric ammonium nitrate (CAN) in the presence of substituted cyclopropyl alcohols provides a novel approach to beta-functionalized ketones. The protocol has a number of advantages including short reaction times, ease of reagent handling, and mild, neutral reaction conditions. Overall, this method provides an alternative pathway to important starting materials and intermediates in organic synthesis.