Engineering glucose-responsive insulin
Engineering glucose-responsive insulin
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DOI：
10.1016/j.medidd.2019.100010
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发表时间：
2019-09
影响因子：
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通讯作者：
Yi Zeng;Jinqiang Wang;Zhongze Gu;Zheng Gu
中科院分区：
文献类型：
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作者：
Yi Zeng;Jinqiang Wang;Zhongze Gu;Zheng Gu
1型或晚期2型糖尿病患者高度依赖胰岛素。然而，胰岛素无法使其功能与每日变化的血糖水平相匹配，从而使糖尿病患者面临低血糖的风险。血糖响应型胰岛素能够改善血糖调节，提高糖尿病患者的生活质量。因此，人们一直致力于开发葡萄糖响应型胰岛素制剂，包括葡萄糖响应型胰岛素递送系统和葡萄糖响应型胰岛素类似物。在这篇综述中，我们重点介绍了葡萄糖反应性胰岛素类似物，特别是三个代表性的类似物，包括苯基硼酸介导的类似物、葡萄糖转运体介导的类似物和凝集素介导的葡萄糖反应性胰岛素类似物。在已发表研究的基础上，还讨论了设计葡萄糖响应型胰岛素类似物的机遇和挑战。
People with type 1 or advanced type 2 diabetes are highly dependent on insulin. However, insulin cannot match its function to daily varying blood glucose levels, putting people with diabetes at risk of hypoglycemia. Glucose-responsive insulin is capable of improving blood glucose manipulation and elevating the life quality of people with diabetes. Therefore, enormous endeavors have been devoted to developing glucose-responsive insulin formulations, including glucose-responsive insulin delivery systems and glucose-responsive insulin analogs. In this review, we focus on glucose-responsive insulin analogs, especially three representatives, including phenylboronic acid-mediated, glucose transporter-mediated and lectin-mediated glucose-responsive insulin analogs. Based on the published studies, the opportunities and challenges to engineering glucose-responsive insulin analogs are also discussed.