The Asymmetric Friedel-Crafts Reaction of Indoles with Fluoroalkylated Nitroalkenes Catalyzed by Chiral Phosphoric Acid
The Asymmetric Friedel-Crafts Reaction of Indoles with Fluoroalkylated Nitroalkenes Catalyzed by Chiral Phosphoric Acid
复制标题
手性磷酸催化吲哚与氟烷基硝基烯烃的不对称傅克反应
DOI：
10.1002/ejoc.201100683
复制
发表时间：
2011-08-01
影响因子：
2.8
通讯作者：
Xiao, Ji-Chang
中科院分区：
文献类型：
--
作者：
Lin, Jin-Hong;Xiao, Ji-Chang
本文报道了在手性磷酸催化下吲哚与氟烷基化硝基烯烃的不对称Friedel-Crafts氟烷基化反应。氟烷基化硝基烯烃的区域选择性是一个值得讨论的问题，研究发现与氟烷基相邻的碳原子比与NO2基团相邻的碳原子反应活性更高。
The enantioselective Friedel Crafts fluoroalkylation of indoles with fluoroalkylated nitroalkenes, catalyzed by chiral phosphoric acid is described. The regioselectivity of fluoroalkylated nitroalkenes is a problem worth discussing, and it was found that the carbon atom adjacent to the fluoroalkyl group is more reactive than that adjacent to NO2 group.