WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition
WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition
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DOI：
10.1097/pat.0000000000000050
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发表时间：
2014-02-01
期刊：
影响因子：
4.5
通讯作者：
Fletcher, Christopher D. M.
中科院分区：
文献类型：
--
作者：
Jo, Vickie Y.;Fletcher, Christopher D. M.
世界卫生组织（WHO）软组织和骨肿瘤分类第四版于2013年2月发布，旨在为病理学家提供更新的分类方案和可重复的诊断标准。鉴于软组织肿瘤的相对罕见性和免疫组化和遗传/分子发展的快速速度（经常促进新肿瘤实体的识别），这一更新的文本由共识小组编辑，对执业病理学家和肿瘤学家都很重要。2013年世卫组织分类包括软组织肿瘤分类的几项变化，包括几个新实体（例如，假肌源性血管内皮瘤、含铁血黄素纤维脂肪瘤和肢端纤维粘液瘤），分别为胃肠道间质瘤、神经鞘肿瘤和未分化/未分类软组织肿瘤的3个新纳入切片，各种“重新分类”肿瘤，以及大量新的基因和分子数据，这些数据有助于更好地定义肿瘤类型，并可用作诊断工具。本文根据2013年WHO软组织肿瘤分类简要概述了这些更新。
The fourth edition of the World Health Organization (WHO) Classification of Tumours of Soft Tissue and Bone was published in February 2013, and serves to provide an updated classification scheme and reproducible diagnostic criteria for pathologists. Given the relative rarity of soft tissue tumours and the rapid rate of immunohistochemical and genetic/molecular developments (not infrequently facilitating recognition of new tumour entities), this updated text edited by a consensus group is important for both practising pathologists and oncologists. The 2013 WHO classification includes several changes in soft tissue tumour classification, including several new entities (eg, pseudomyogenic haemangioendothelioma, haemosiderotic fibrolipomatous tumour, and acral fibromyxoma), three newly included sections for gastrointestinal stromal tumours, nerve sheath tumours, and undifferentiated/unclassified soft tissue tumours, respectively, various ‘reclassified’tumours, and a plethora of new genetic and molecular data for established tumour types that facilitate better definition and are useful as diagnostic tools. This article briefly outlines these updates based on the 2013 WHO classification of soft tissue tumours.