Kinetics of prion growth
Kinetics of prion growth
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DOI：
10.1016/s0006-3495(03)74767-5
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发表时间：
2003-12-01
影响因子：
3.4
通讯作者：
Frömmel, C
中科院分区：
文献类型：
--
作者：
Pöschel, T;Brilliantov, NV;Frömmel, C
我们通过数值实验，研究了用成核聚合模型解析描述的蛋白原纤维生长的动力学。Pron纤维形成的基本过程将我们引向一组关于纤丝数量、其总质量和Prion单体数量的微分方程式。与以前的研究不同的是，我们通过显式地考虑Prion单体浓度的时间依赖性来分析这一集合。理论结果与实验数据吻合，而普遍接受的单体浓度恒定的假设导致了纤维的生长行为，这与实验不一致。与以前的结果相比，获得的Pron原纤维聚集体的大小分布显著地向较短的长度移动，这导致Pron材料的传染性增强。最后，我们研究了接种材料的过滤对该病潜伏期的影响。
We study the kinetics of prion fibril growth, described by the nucleated polymerization model analytically and by means of numerical experiments. The elementary processes of prion fibril formation lead us to a set of differential equations for the number of fibrils, their total mass, and the number of prion monomers. In difference to previous studies we analyze this set by explicitly taking into account the time-dependence of the prion monomer concentration. The theoretical results agree with experimental data, whereas the generally accepted hypothesis of constant monomer concentration leads to a fibril growth behavior which is not in agreement with experiments. The obtained size distribution of the prion fibril aggregates is shifted significantly toward shorter lengths as compared to earlier results, which leads to a enhanced infectivity of the prion material. Finally, we study the effect of filtering of the inoculated material on the incubation time of the disease.