INACTIVATION OF SERUM RIBONUCLEASE BY THE KIDNEY
INACTIVATION OF SERUM RIBONUCLEASE BY THE KIDNEY
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DOI：
10.1152/ajplegacy.1959.196.4.924
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发表时间：
1959-01-01
影响因子：
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通讯作者：
RABINOVITCH, M
中科院分区：
文献类型：
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作者：
DOHI, SR;TERZIAN, JF;RABINOVITCH, M
输尿管静脉吻合术(UVA)用于研究肾脏对血清核糖核酸酶(RNase)的灭活作用。术后2小时酶活性显著升高，随后8小时恢复至接近术前水平。这一行为与双侧肾切除犬的行为形成对比，在双侧肾切除犬中，活动急剧上升到高水平，并在此后保持不变。在两组动物中，血清肌酐的行为相似。输注尿液不影响肾切除犬核糖核酸酶活性的升高。当肾切除时，UVA动物能够通过血清核糖核酸酶的升高做出反应。在紫外线照射犬体内观察到静脉注射血红蛋白的红细胞增多症。这些发现与肾小球滤过加肾小管重吸收和破坏部分血浆核糖核酸酶的机制是一致的。
The ureterovenous anastomosis preparation (U. V. A.) was used to study the inactivation of serum ribonuclease (RNase) by the kidneys. Asignificant increase was found in the enzyme activity 2 hours after the operation, with a return to levels close to the initial ones in succeeding periods up to 8 hours. This behavior contrasted with that of bilaterally nephrectomized dogs where activity steeply rose to high levels and was thereafter maintained. The behavior of serum creatinine was similar in both groups of animals. Infusion of urine did not influence the RNase activity increase of nephrectomized dogs. U. V. A. animals, when nephrectomized, were able to respond with increases in serum RNase. Athrocytosis of intravenously injected hemoglobin was observed in U. V. A. dogs. It is suggested that these findings agree with the hypothesis of a mechanism of glomerular filtration plus tubular reabsorption and destruction of part of the plasma RNase.