Genetic Variation in the TAS2R38 Bitter Taste Receptor and Gastric Cancer Risk in Koreans
Genetic Variation in the TAS2R38 Bitter Taste Receptor and Gastric Cancer Risk in Koreans
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DOI：
10.1038/srep26904
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发表时间：
2016-06-01
影响因子：
4.6
通讯作者：
Kim, Jeongseon
中科院分区：
文献类型：
--
作者：
Choi, Jeong-Hwa;Lee, Jeonghee;Kim, Jeongseon
人类 TAS2R38 基因编码苦味受体，可调节口腔和胃肠道中摄入的营养/有毒化合物的苦味感知和分化。 TAS2R38 基因变异与个体对苦味和食物摄入敏感性的改变有关；因此，这些遗传变异可能会改变饮食相关疾病（包括癌症）的风险。然而，人们对TAS2R38多态性与胃癌易感性之间的关系知之甚少。本病例对照研究检查了 TAS2R38 多态性对食物摄入的影响，并确定它们是否可以预测韩国人患胃癌的风险。共有 1,580 名受试者（包括 449 名胃癌病例）进行了 TAS2R38 A49P、V262A、I296V 和双倍型基因分型。分析膳食数据以确定能量、纤维、蔬菜、水果、糖果、脂肪、酒精和香烟的总消耗量。 TAS2R38 双倍型与食物、酒精或香烟的消费无关，无论是独立的还是依赖于胃癌表型。然而，PAV/AVI 双倍型显着增加胃癌风险（调整后优势比：1.513；95% 置信区间：1.148-1.994），与饮食摄入量无关。研究结果表明，尽管 TAS2R38 双倍型不影响饮食摄入量，但 TAS2R38 可能与韩国人患胃癌的风险相关。
The human TAS2R38 gene encodes a bitter taste receptor that regulates the bitterness perception and differentiation of ingested nutritional/poisonous compounds in the oral cavity and gastrointestinal tract. TAS2R38 gene variants are associated with alterations in individual sensitivity to bitter taste and food intake; hence, these genetic variants may modify the risk for diet-related diseases, including cancer. However, little is known about the association between TAS2R38 polymorphisms and gastric cancer susceptibility. The present case-control study examined the influence of TAS2R38 polymorphisms on food intake and determined whether they predict gastric cancer risk in Koreans. A total of 1,580 subjects, including 449 gastric cancer cases, were genotyped for TAS2R38 A49P, V262A, I296V and diplotypes. Dietary data were analysed to determine the total consumption of energy, fibre, vegetables, fruits, sweets, fats, alcohol and cigarettes. TAS2R38 diplotype was not associated with food, alcohol or cigarette consumption, either independent or dependent of gastric cancer phenotype. However, the PAV/AVI diplotype significantly increased gastric cancer risk (adjusted odds ratio: 1.513; 95% confidence interval: 1.148-1.994) independent of dietary intake. Findings suggest that TAS2R38 may be associated with the risk for gastric cancer in Koreans, although the TAS2R38 diplotype did not influence dietary intake.