THE RAT-BRAIN POSTSYNAPTIC DENSITY FRACTION CONTAINS A HOMOLOG OF THE DROSOPHILA DISKS-LARGE TUMOR SUPPRESSOR PROTEIN
THE RAT-BRAIN POSTSYNAPTIC DENSITY FRACTION CONTAINS A HOMOLOG OF THE DROSOPHILA DISKS-LARGE TUMOR SUPPRESSOR PROTEIN
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DOI：
10.1016/0896-6273(92)90245-9
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发表时间：
1992-11-01
期刊：
影响因子：
16.2
通讯作者：
KENNEDY, MB
中科院分区：
文献类型：
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作者：
CHO, KO;HUNT, CA;KENNEDY, MB
在中枢神经系统突触中，突触连接复合物与相关的突触后密度被认为含有负责突触前和突触后膜之间的粘附和突触后信号转导的蛋白质。我们已经发现，一个突出的，脑特异性蛋白质（PSD-95）富集在突触后密度部分从大鼠大脑是高度相似的果蝇致死（1）discs-large-1（dlg）肿瘤抑制蛋白。dlg蛋白与发育中的果蝇中的分隔连接有关，并且包含细胞分裂的正常控制所需的鸟苷酸激酶结构域。dlg和PSD-95之间的序列相似性表明，在发育生物体中对生长控制至关重要的分子机制也可以调节成年大脑中突触的形成、稳定或功能。
In CNS synapses, the synaptic junctional complex with associated postsynaptic density is presumed to contain proteins responsible for adhesion between pre- and postsynaptic membranes and for postsynaptic signal transduction. We have found that a prominent, brain-specific protein (PSD-95) enriched in the postsynaptic density fraction from rat brain is highly similar to the Drosophila lethal(1)discs-large-1 (dlg) tumor suppressor protein. The dlg protein is associated with septate junctions in developing flies and contains a guanylate kinase domain that is required for normal control of cell division. The sequence similarity between dlg and PSD-95 suggests that molecular mechanisms critical for growth control in developing organisms may also regulate synapse formation, stabilization, or function in the adult brain.