Lymphotoxin targeted to salivary and lacrimal glands induces tertiary lymphoid organs and cervical lymphadenopathy and reduces tear production.
Lymphotoxin targeted to salivary and lacrimal glands induces tertiary lymphoid organs and cervical lymphadenopathy and reduces tear production.
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针对唾液腺和泪腺的淋巴毒素会诱发第三淋巴器官和颈部淋巴结病，并减少泪液的产生。
DOI：
10.1002/eji.201948300
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发表时间：
2020
影响因子：
5.4
通讯作者：
Ruddle,NancyH
中科院分区：
文献类型：
--
作者：
Truman,LucyA;Bentley,KevinL;Ruddle,NancyH
为了研究光敏素（LT）在干燥综合征（SS）和粘膜相关淋巴组织（MALT）-淋巴瘤中的作用，我们制作了将LTα和LTβ靶向唾液腺和泪腺的转基因小鼠（Amy 1-LTαβ）。Amy 1-LTαβ小鼠出现萎缩性唾液腺和泪腺，其中含有三级淋巴器官（TLO），泪液分泌减少。Amy 1-LTαβ小鼠出现颈部淋巴结病，但未出现MALT-淋巴瘤。通过自身抗体滴度测定，Amy 1-LTαβ唾液腺和泪腺中的TLO形成不足以诱导自身免疫。
To investigate the role of lymphotoxin (LT) in Sjögren's syndrome (SS) and in mucosal associated lymphoid tissue (MALT)‐lymphoma, we made transgenic mice (Amy1‐LTαβ) that targeted LTα and LTβ to the salivary and lacrimal glands. Amy1‐LTαβ mice developed atrophic salivary and lacrimal glands that contained tertiary lymphoid organs (TLOs) and had reduced tear production. Amy1‐LTαβ mice developed cervical lymphadenopathy but not MALT‐lymphoma. TLO formation in the salivary and lacrimal glands of Amy1‐LTαβ was not sufficient to induce autoimmunity as measured by autoantibody titres.