Rotating magnetic particle microrheometry in biopolymer fluid dynamics: Mucus microrheology
Rotating magnetic particle microrheometry in biopolymer fluid dynamics: Mucus microrheology
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DOI：
10.1063/1.2766947
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发表时间：
2007-09-14
影响因子：
4.4
通讯作者：
Yeates, Donovan B.
中科院分区：
文献类型：
--
作者：
Besseris, George J.;Yeates, Donovan B.
The polymer properties of canine mucus were investigated through the method of rotating magnetic particle microrheometry. Mucus is visualized as a physically entangled biopolymer of low polydispersity in a water-based solution. Mucus was modeled according to the constitutive law of a Doi-Edwards fluid. The magnetic-particle equation of rotational motion is analytically solved in the linear viscoelastic limit rendering theoretical flow profiles which are used to fit the experimental trace signals of the particle remanent-magnetic-field decay. The zero-shear-rate viscosity was found to be 18 000 P and the relaxation time at about 42 s. The molecular weight between entanglements for mucins was estimated at 1.7 MDa rendering an estimation of about seven physical cross-links per molecule. Rheological investigations were extended also to diluted and concentrated rations of the normal mucus simulating the conditions found in more physiological extremes.
