Links between ectopic fat and vascular disease in humans.
Links between ectopic fat and vascular disease in humans.
复制标题
DOI：
10.1161/atvbaha.114.303035
复制
发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Meigs JB
中科院分区：
文献类型：
--
作者：
Lim S;Meigs JB
平均超重个体在目标器官或身体的特定部位可能有不同的脂肪储存。这种异位脂肪分布可能比肥胖更能预测心血管风险。腹部内脏肥胖是一种典型的异位脂肪，与胰岛素抵抗和心血管风险密切相关。肝脏和肌肉组织中的脂肪储存通过影响葡萄糖和脂质代谢而引起不良的心脏代谢风险。心包脂肪和血管周围脂肪影响冠状动脉粥样硬化、心功能和血流动力学。脖子周围的脂肪与全身血管阻力有关。肾脏周围的脂肪可使血压升高并诱发蛋白尿。胰腺内部或周围的脂肪堆积会改变葡萄糖代谢，增加心血管风险。异位脂肪可能作为一种活跃的内分泌和旁分泌器官，释放各种生物活性介质，影响胰岛素抵抗、糖脂代谢、凝血和炎症，这些都有助于心血管风险。由于肥胖和明显瘦弱的个体都可能有异位脂肪，因此区域脂肪分布可能在非肥胖和肥胖人群的心血管疾病发展中起重要作用。
The average of overweight individual can have differential fat depots in target-organs or specific compartments of the body. This ectopic fat distribution may be more of a predictive factor for cardiovascular risk than obesity. Abdominal visceral obesity, a representative ectopic fat, is robustly associated with insulin resistance and cardiovascular risk. Fat depots in the liver and muscle tissue cause adverse cardiometabolic risk by affecting glucose and lipid metabolism. Pericardial fat and perivascular fat affect coronary atherosclerosis, cardiac function, and hemodynamics. Fat around the neck is associated with systemic vascular resistance. Fat around the kidney may increase blood pressure and induce albuminuria. Fat accumulation in or around the pancreas alters glucose metabolism, conferring cardiovascular risk. Ectopic fat may act as an active endocrine and paracrine organ that releases various bioactive mediators that influence insulin resistance, glucose and lipid metabolism, coagulation, and inflammation, which all contribute to cardiovascular risk. As both obese and apparently lean individuals can have ectopic fat, regional fat distribution may play an important role in the development of cardiovascular diseases in both non-obese and obese people.