Unexpected improvements of spatial learning and memory abilities in chronic rotenone intoxicated mice.
Unexpected improvements of spatial learning and memory abilities in chronic rotenone intoxicated mice.
复制标题
慢性鱼藤酮中毒小鼠空间学习和记忆能力的意外改善
DOI：
10.1371/journal.pone.0091641
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Jiang H
中科院分区：
文献类型：
--
作者：
Jia F;Song N;Zhao C;Xie J;Jiang H
The liposoluble insecticide rotenone is commonly used as a mitochondrial complex I inhibitor to replicate Parkinson's disease (PD) pathological features. However, there was no assessment of the spatial learning and memory abilities in chronic rotenone-induced PD models. In the present study, by rotarod test and Thioflavine T staining, we first noted the impairment of motor coordination in rotenone-treated group for 3 months, as well as alpha-synuclein inclusions in the nigral dopaminergic neurons in C57BL/6 mice with intragastrical delivery of rotenone (5 mg/Kg) for 3 months rather than 1 month. We then evaluated spatial learning and memory abilities by Morris water maze task in this model. The results showed escape latency reduced in rotenone-intoxicated mice for 3 months, indicating an improvement of learning ability. However, it was delayed slightly but not significantly in rotenone-intoxicated mice for 1 month. Similarly, we demonstrated that spatial memory ability was enhanced in 3-month-treatment group, but impaired in 1-month-treatment group. There were no proliferating cell nuclear antigen and doublecortin positive cells in the hippocampus by double immunofluorescent staining, indicating the absence of hippocampal neurogenesis in rotenone-intoxicated mice. These results suggest that spatial learning and memory abilities are disturbed in chronic rotenone-intoxicated PD model.
登录
查看更多内容
影响因子：
3.7
作者：
Nielsen SB;Macchi F;Raccosta S;Langkilde AE;Giehm L;Kyrsting A;Svane AS;Manno M;Christiansen G;Nielsen NC;Oddershede L;Vestergaard B;Otzen DE
通讯作者：
Otzen DE
影响因子：
--
作者：
Aulić S;Bolognesi ML;Legname G
通讯作者：
Legname G
影响因子：
3.7
作者：
Moreira, Camila G.;Barbiero, Janaina K.;Lima, Marcelo M. S.
通讯作者：
Lima, Marcelo M. S.
影响因子：
11.1
作者：
Chinta SJ;Lieu CA;Demaria M;Laberge RM;Campisi J;Andersen JK
通讯作者：
Andersen JK
影响因子：
5.3
作者：
Greene, James G.;Noorian, Ali Reza;Srinivasan, Shanthi
通讯作者：
Srinivasan, Shanthi