Dopamine Modulates Delta-Gamma Phase-Amplitude Coupling in the Prefrontal Cortex of Behaving Rats.
Dopamine Modulates Delta-Gamma Phase-Amplitude Coupling in the Prefrontal Cortex of Behaving Rats.
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DOI：
10.3389/fncir.2017.00029
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发表时间：
2017
影响因子：
3.5
通讯作者：
Ribeiro S
中科院分区：
文献类型：
--
作者：
Andino-Pavlovsky V;Souza AC;Scheffer-Teixeira R;Tort ABL;Etchenique R;Ribeiro S
多巴胺释放和相位幅度交叉频率耦合（CFC）独立地与前额皮质（PFC）功能相关。为了因果研究多巴胺的释放是否影响从行为大鼠的内侧 PFC (mPFC) 记录的局部场电位 (LFP) 中不同频率之间的相位幅度共调制，我们使用了 RuBiDopa，一种光敏笼状化合物，在可见光照射时释放神经递质多巴胺。应用光笼蔽多巴胺后，LFP功率在任何频段都没有变化，但显着增强了delta和gamma振荡之间的相位幅度共调制。盐水没有产生显着的变化，而注射多巴胺和RuBiDopa在注射后几分钟内产生共调节的缓慢增加。结果表明，内侧 PFC 中的多巴胺释放将相位幅度共调制从 theta-gamma 转变为 delta-gamma。尽管由于本研究中动物数量较少，只是初步结果，但我们的研究结果表明，多巴胺介导的共调制频率修饰可能是这种神经递质调节 mPFC 功能的机制。
Dopamine release and phase-amplitude cross-frequency coupling (CFC) have independently been implicated in prefrontal cortex (PFC) functioning. To causally investigate whether dopamine release affects phase-amplitude comodulation between different frequencies in local field potentials (LFP) recorded from the medial PFC (mPFC) of behaving rats, we used RuBiDopa, a light-sensitive caged compound that releases the neurotransmitter dopamine when irradiated with visible light. LFP power did not change in any frequency band after the application of light-uncaged dopamine, but significantly strengthened phase-amplitude comodulation between delta and gamma oscillations. Saline did not exert significant changes, while injections of dopamine and RuBiDopa produced a slow increase in comodulation for several minutes after the injection. The results show that dopamine release in the medial PFC shifts phase-amplitude comodulation from theta-gamma to delta-gamma. Although being preliminary results due to the limitation of the low number of animals present in this study, our findings suggest that dopamine-mediated modification of the frequencies involved in comodulation could be a mechanism by which this neurotransmitter regulates functioning in mPFC.