Gut microbiota-involved mechanisms in enhancing systemic exposure of ginsenosides by coexisting polysaccharides in ginseng decoction.
Gut microbiota-involved mechanisms in enhancing systemic exposure of ginsenosides by coexisting polysaccharides in ginseng decoction.
复制标题
人参汤中共存多糖增强人参皂苷全身暴露的肠道菌群相关机制
DOI：
10.1038/srep22474
复制
发表时间：
2016-03-02
影响因子：
4.6
通讯作者：
Li SL
中科院分区：
文献类型：
--
作者：
Zhou SS;Xu J;Zhu H;Wu J;Xu JD;Yan R;Li XY;Liu HH;Duan SM;Wang Z;Chen HB;Shen H;Li SL
几个世纪以来，中药口服煎剂一直用于疾病的治疗和预防管理。小分子和多糖是中药汤剂中共同存在的主要化学物质。通过多学科的研究，小分子分子得到了很好的研究，而多糖的作用在很大程度上仍然难以捉摸。在这里，我们探索了一个涉及肠道微生物群的机制，通过中药多糖恢复肠道微生物群的稳态，从而促进汤中伴随的小分子的全身暴露。以人参多糖和人参皂苷为研究对象，在过疲劳急性冷应激模型上进行研究。结果表明，人参多糖改善了肠道代谢和某些人参皂苷的吸收，同时恢复了受干扰的整体肠道微生物群，特别是促进了人参皂苷的两种主要代谢菌乳酸杆菌和拟杆菌的生长。通过探索多糖与小分子的协同作用，为中药经典煎剂在人体保健中的科学化和合理化提供了新的思路。
Oral decoctions of traditional Chinese medicines (TCMs) serve for therapeutic and prophylactic management of diseases for centuries. Small molecules and polysaccharides are the dominant chemicals co-occurred in the TCM decoction. Small molecules are well-studied by multidisciplinary elaborations, whereas the role of polysaccharides remains largely elusive. Here we explore a gut microbiota-involved mechanism by which TCM polysaccharides restore the homeostasis of gut microbiota and consequently promote the systemic exposure of concomitant small molecules in the decoction. As a case study, ginseng polysaccharides and ginsenosides in Du-Shen-Tang, the decoction of ginseng, were investigated on an over-fatigue and acute cold stress model. The results indicated that ginseng polysaccharides improved intestinal metabolism and absorption of certain ginsenosides, meanwhile reinstated the perturbed holistic gut microbiota, and particularly enhanced the growth of Lactobacillus spp. and Bacteroides spp., two major metabolic bacteria of ginsenosides. By exploring the synergistic actions of polysaccharides with small molecules, these findings shed new light on scientization and rationalization of the classic TCM decoctions in human health care.