The human blood DNA methylome displays a highly distinctive profile compared with other somatic tissues.
The human blood DNA methylome displays a highly distinctive profile compared with other somatic tissues.
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DOI：
10.1080/15592294.2014.1003744
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Rakyan VK
中科院分区：
文献类型：
--
作者：
Lowe R;Slodkowicz G;Goldman N;Rakyan VK
在哺乳动物中，不同组织的DNA甲基化谱差异很大。最近的基因组规模研究报告称，血液显示出与其他体细胞组织高度不同的甲基组谱。在这项研究中，我们试图理解为什么血液DNA甲基化状态与其他组织中的甲基化状态如此不同。我们发现，全血中组织特异性差异甲基化位点（tDMPs）的含量大约是其他体细胞组织的两倍。此外，很大一部分血液tDMPs的甲基化水平远低于其他组织的tDMPs。令人惊讶的是，与其他tdmp相比，血液中这些低甲基化区域在基因组位置、基因组含量、进化速率或组蛋白标记方面没有差异。我们的研究结果揭示了为什么血液相对于其他体细胞组织显示出独特的甲基化特征。在未来，研究这些血液特异性tdmp是如何参与血液特异性功能的机制将是很重要的。
In mammals, DNA methylation profiles vary substantially between tissues. Recent genome-scale studies report that blood displays a highly distinctive methylomic profile from other somatic tissues. In this study, we sought to understand why blood DNA methylation state is so different to the one found in other tissues. We found that whole blood contains approximately twice as many tissue-specific differentially methylated positions (tDMPs) than any other somatic tissue examined. Furthermore, a large subset of blood tDMPs showed much lower levels of methylation than tDMPs for other tissues. Surprisingly, these regions of low methylation in blood show no difference regarding genomic location, genomic content, evolutionary rates, or histone marks when compared to other tDMPs. Our results reveal why blood displays a distinctive methylation profile relative to other somatic tissues. In the future, it will be important to study how these blood specific tDMPs are mechanistically involved in blood-specific functions.