Moderation of the platelet releasate response by aspirin
Moderation of the platelet releasate response by aspirin
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DOI：
10.1182/blood-2006-07-038539
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发表时间：
2007-06-01
期刊：
影响因子：
20.3
通讯作者：
Cagney, Gerard
中科院分区：
文献类型：
--
作者：
Coppinger, Judith A.;O'Connor, Roisin;Cagney, Gerard
Modulation of the proteins released during activation is one mechanism whereby aspirin may influence platelet-mediated human disease. We investigated the effect of aspirin on the platelet releasate using mass spectrometry and found that different agonists evoked different releasate profiles, with aspirin having a general moderating effect on the amount of protein released regardless of the agonist. These observations were confirmed for several cytokines using an antibody array approach.
