Surface Modification of Poly(dimethylsiloxane) with Polydopamine and Hyaluronic Acid To Enhance Hemocompatibility for Potential Applications in Medical Implants or Devices.
Surface Modification of Poly(dimethylsiloxane) with Polydopamine and Hyaluronic Acid To Enhance Hemocompatibility for Potential Applications in Medical Implants or Devices.
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DOI：
10.1021/acsami.7b10260
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发表时间：
2017-09
影响因子：
9.5
通讯作者：
P. Xue;Qian Li;Yuan Li;Lihong Sun;Lei Zhang;Zhigang Xu;Yuejun Kang
中科院分区：
文献类型：
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作者：
P. Xue;Qian Li;Yuan Li;Lihong Sun;Lei Zhang;Zhigang Xu;Yuejun Kang
聚二甲基硅氧烷（PDMS）在微机电系统（MEMS）和植入式器件中得到了广泛的应用。为了改善PDMS基植入物的血液相容性，开发了一种简单的技术，通过用透明质酸（HA）和聚多巴胺（PDA）复合物（HA/PDA）修饰PDMS。在适当的HA/PDA比例下，改性PDMS基底上的血小板粘附和活化显著降低，表明与天然PDMS或仅涂覆有HA或PDA的那些相比，增强的血液相容性。HA/PDA涂层对内皮细胞（HUVEC）的粘附和增殖也具有极低的细胞毒性。基于粘附巨噬细胞中关键细胞因子的表达来表征修饰的PDMS表面的抗炎作用。该研究表明，可以通过调节改性PDMS表面上HA和PDA复合物的比例来方便地定制血液相容性、细胞毒性和抗炎性质，其具有作为构建生物医学应用中的可植入装置的核心或包装材料的特殊潜力。
Poly(dimethylsiloxane) (PDMS) has been widely utilized in micro-electromechanical systems (MEMS) and implantable devices. To improve the hemocompatibility of a PDMS-based implant, a facile technique was developed by modifying PDMS with a hyaluronic acid (HA) and polydopamine (PDA) composite (HA/PDA). Under appropriate ratio of HA to PDA, platelet adhesion and activation were considerably reduced on modified PDMS substrates, indicating an enhanced hemocompatibility compared to native PDMS or those coated with HA or PDA solely. HA/PDA coating also posed minimal cytotoxicity on the adhesion and proliferation of endothelial cells (HUVECs). The anti-inflammation effect of the modified PDMS surface was characterized based on the expression of critical cytokines in adherent macrophages. This study revealed that the hemocompatibility, cytotoxicity, and anti-inflammation properties could be tailored conveniently by adjusting the ratio of HA and PDA composite on the modified PDMS surface, which has an exceptional potential as the core or packaging material for constructing implantable devices in biomedical applications.