The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion.
The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion.
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新型神经肽孤啡肽 FQ 无法产生条件性位置偏好或厌恶。
DOI：
10.1016/0006-8993(96)00476-3
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发表时间：
1996
期刊：
影响因子：
2.9
通讯作者：
Akil,H
中科院分区：
文献类型：
--
作者：
Devine,DP;Reinscheid,RK;MonsmaJr,FJ;Civelli,O;Akil,H
使用无偏倚的条件性位置偏爱程序来确定新发现的神经肽孤啡肽FQ在脑室内微量注射后是否产生兴奋作用。微量注射孤啡肽(0.1-100nmol)不能产生条件性位置偏爱或厌恶，但在两个最高剂量的条件反射过程中观察到明显的运动障碍。因此，孤儿FQ在给予行为活跃剂量时似乎缺乏激励作用。
An unbiased conditioned place preference procedure was used to determine whether the newly-identified neuropeptide orphanin FQ produced motivational effects after intracerebroventricular microinjections. Microinjections of orphanin FQ (0.1–100 nmol) failed to produce conditioned place preference or aversion, but a pronounced motor impairment was observed during conditioning sessions with the two highest doses. Thus, it appears that orphanin FQ lacks motivational effects when administered at behaviourally active doses.