N-arylimidazole synthesis by cross-cycloaddition of isocyanides using a novel catalytic system
N-arylimidazole synthesis by cross-cycloaddition of isocyanides using a novel catalytic system
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DOI：
10.1016/j.tet.2007.03.152
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发表时间：
2007-06-04
期刊：
影响因子：
2.1
通讯作者：
Roy, Rene
中科院分区：
文献类型：
--
作者：
Bonin, Marc-Andre;Giguere, Denis;Roy, Rene
以N-芳基甲酰胺和N-甲酰甘氨酸酯为原料直接催化合成了N-芳基咪唑。应用于不同的芳基取代的吸电子和给电子基团提供了类似的杂环化合物在非常高的产率。氧化铜（I）/脯氨酸催化剂的使用允许反应在室温下进行。本文还首次合成了含糖基的N-芳基咪唑。(c)2007爱思唯尔有限公司保留所有权利。
A direct catalytic synthesis of N-arylimidazoles starting from the corresponding N-arylformamides and N-formylglycine esters is described. Application to different aryl substituted electron-withdrawing and -donating groups provided the analogous heterocyclic compounds in very high yields. The use of copper(I) oxide/proline catalysts allowed the reactions to proceed at room temperature. The first synthesis of N-arylimidazole bearing carbohydrate moieties is also described. (c) 2007 Elsevier Ltd. All rights reserved.