Intervertebral disc height in treated and untreated overweight post-menopausal women
Intervertebral disc height in treated and untreated overweight post-menopausal women
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DOI：
10.1093/humrep/dei251
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发表时间：
2005-12-01
影响因子：
6.1
通讯作者：
Calleja, N
中科院分区：
文献类型：
--
作者：
Baron, YM;Brincat, MP;Calleja, N
背景：绝经和激素替代疗法对椎间盘的影响尚未见报道。方法：招募了100名妇女，包括44名接受HRT的绝经后妇女，33名未经治疗的绝经后妇女和23名绝经前妇女。利用骨密度仪高度光标测量第12胸椎和第3腰椎之间的椎间盘高度。结果：未经治疗的绝经组女性的总椎间盘高度最低（D1-D3：1.95 +/-0.31 cm）。这显著低于绝经前组（D1-D3：2.16 +/-0.24 cm）和绝经后治疗组（2.2 +/-0.26 cm）（P> 0.02）。第2椎间盘在未治疗的绝经组（D2：0.63 ± 0.13）与其他两组（绝经前组（D2：0.72 ± 0.09 cm）和治疗的绝经组（D2：0.73 ± 0.12 cm））之间始终保持显著差异（P> 0.02）。结论：与未经治疗的绝经后妇女相比，雌激素充足的妇女似乎维持更高的椎间盘。雌激素环境可能是相关的，因为它对椎间盘的亲水性糖胺聚糖、含水量、胶原蛋白和弹性蛋白具有显著影响。保持足够的椎间盘高度可以使椎间盘保持其盘状形状和粘弹性功能，包含可能威胁脊柱结构导致椎体压缩性骨折的垂直力。
BACKGROUND: The effect of the menopause and HRT on the intervertebral discs has not been investigated. METHODS: One hundred women were recruited, comprising of 44 post-menopausal women on HRT, 33 untreated post-menopausal women and 23 pre-menopausal women. The height of the intervertebral discs between the 12th thoracic vertebra and the 3rd lumbar vertebra was measured by utilizing the bone densitometer height cursors. RESULTS: The untreated menopausal group of women had the lowest total disc height (D1-D3: 1.95 +/- 0.31 cm). This was significantly lower than the pre-menopausal group D1-D3: 2.16 +/- 0.24 cm) and the hormone-treated group (2.2 +/- 0.26 cm) (P > 0.02). The 2nd intervertebral disc consistently maintained a significant difference between the untreated menopausal group (D2: 0.63 +/- 0.13) and the other two groups (pre-menopausal group (D2: 0.72 +/- 0.09 cm) and treated menopausal group (D2: 0.73 +/- 0.12 cm) (P > 0.02). CONCLUSIONS: Estrogen-replete women appear to maintain higher intervertebral discs compared to untreated post-menopausal women. The estrogenic milieu may be relevant because of the significant impact it has on the hydrophilic glycosaminoglycans, the water content, collagen and elastin of the intervertebral discs. The maintenance of adequate disc height may allow the intervertebral discs to retain their discoid shape and viscoelastic function, containing vertical forces which may threaten spinal architecture leading to vertebral body compression fractures.