Senescent T Cell Induces Brown Adipose Tissue "Whitening" Via Secreting IFN-γ.
Senescent T Cell Induces Brown Adipose Tissue "Whitening" Via Secreting IFN-γ.
复制标题
衰老 T 细胞通过分泌 IFN-γ 诱导棕色脂肪组织“美白”
DOI：
10.3389/fcell.2021.637424
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发表时间：
2021
影响因子：
5.5
通讯作者：
Wu F
中科院分区：
文献类型：
--
作者：
Pan XX;Yao KL;Yang YF;Ge Q;Zhang R;Gao PJ;Ruan CC;Wu F
衰老相关的慢性炎症是一组慢性代谢紊乱的关键因素，如心血管疾病、肥胖和2型糖尿病。随着年龄的增长，免疫细胞特别是T细胞在脂肪组织中积累，并且T细胞与前脂肪细胞之间存在串扰，有助于与年龄相关的脂肪组织重塑。在这里，我们比较了年轻（3月龄）和老年（18月龄）小鼠之间脂肪组织形态和功能的差异，并显示了老年小鼠棕色脂肪组织（BAT）“变白”的现象。流式细胞仪分析表明，老年小鼠BAT中T细胞的比例比青年小鼠增加，并表现出衰老特征。我们利用共培养系统直接证明衰老T细胞抑制脂肪组织中前脂肪细胞向棕色脂肪细胞分化。从机制上讲，体外和体内研究均表明衰老T细胞产生并释放更高水平的IFN-γ，其在抑制前脂肪细胞向棕色脂肪细胞分化中起关键作用。总之，数据表明衰老T细胞衍生的IFN-γ是棕色脂肪细胞分化中的关键调节因子。
Aging-associated chronic inflammation is a key contributing factor to a cluster of chronic metabolic disorders, such as cardiovascular disease, obesity, and type 2 diabetes. Immune cells particularly T cells accumulate in adipose tissue with advancing age, and there exists a cross talk between T cell and preadipocyte, contributing to age-related adipose tissue remodeling. Here, we compared the difference in morphology and function of adipose tissue between young (3-month-old) and old (18-month-old) mice and showed the phenomenon of brown adipose tissue (BAT) “whitening” in old mice. Flow cytometry analysis suggested an increased proportion of T cells in BAT of old mice comparing with the young and exhibited senescent characteristics. We take advantage of coculture system to demonstrate directly that senescent T cells inhibited brown adipocyte differentiation of preadipocytes in adipose tissue. Mechanistically, both in vitro and in vivo studies suggested that senescent T cells produced and released a higher level of IFN-γ, which plays a critical role in inhibition of preadipocyte-to-brown adipocyte differentiation. Taken together, the data indicate that senescent T cell-derived IFN-γ is a key regulator in brown adipocyte differentiation.
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DOI：
10.1161/atvbaha.114.304636
发表时间：
2014-12
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
McLaughlin T;Liu LF;Lamendola C;Shen L;Morton J;Rivas H;Winer D;Tolentino L;Choi O;Zhang H;Hui Yen Chng M;Engleman E
通讯作者：
Engleman E
影响因子：
7
作者：
Coppack, SW
通讯作者：
Coppack, SW
影响因子：
37.8
作者：
Neeland IJ;Poirier P;Després JP
通讯作者：
Després JP
影响因子：
8
作者：
Moysidou, Maria;Karaliota, Sevasti;Karalis, Katia P.
通讯作者：
Karalis, Katia P.
影响因子：
10.5
作者：
Park, Jeu;Huh, Jin Young;Kim, Jae Bum
通讯作者：
Kim, Jae Bum